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Coenzyme M
go.drugbank.com/drugs/DB09110ApprovedInvestigationalCoenzyme M (commonly known by its salt form, Mesna) is a synthetic sulfhydryl (thiol) compound and is used for prophylaxis of Ifosfamide and cyclophosphamide induced hemorrhagic cystitis.[A18572]
Mixtures: IFEX and MESNEX, IFEX and MESNEXCategories: Cough and Cold PreparationsErgotamine
go.drugbank.com/drugs/DB00696ApprovedIt is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders.
Mixtures: Ergotamine Tartrate and Caffeine, Ergotamine Tartrate and CaffeineCategories: Ergot Alkaloids and DerivativesAbatacept
go.drugbank.com/drugs/DB01281ApprovedInvestigationalAbatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human … [L20504,L42715] Structurally, abatacept is a glycosylated fusion protein with a MALDI-MS molecular weight of 92,300 Da and it is a homodimer of two homologous polypeptide chains of 357 amino acids each
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsProducts: ORENCIA 250MG/VIAL, ORENCIA Injection 125mg/ml in Prefilled SyringeEntrectinib
go.drugbank.com/drugs/DB11986ApprovedInvestigational[L8081] It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positive solid tumors. … This therapy offers benefit over similar ALK inhibitors such as [alectinib], [ceritinib], and [lorlatinib] due to a wider range of targets.[A183929]
Categories: Antineoplastic and Immunomodulating AgentsProducts: ROZLYTREK HARD CAPSULE 100MG, ROZLYTREK CÁPSULAS DURAS 100MGBupropion
go.drugbank.com/drugs/DB01156ApprovedInvestigationalBupropion exerts its pharmacological effects by weakly inhibiting the enzymes involved in the uptake of the neurotransmitters norepinephrine and dopamine from the synaptic cleft, therefore prolonging their … [A178804,A178807] When used as an aid to smoking cessation, bupropion is thought to confer its anti-craving and anti-withdrawal effects by inhibiting dopamine reuptake, which is thought to be involved
Mixtures: Naltrexone Hydrochloride and Bupropion Hydrochloride Extended-ReleaseCategories: bupropion and naltrexone, bupropion and dextromethorphanCeftriaxone
go.drugbank.com/drugs/DB01212ApprovedInvestigationalCeftriaxone has broader and stronger gram-negative coverage then first or second-generation cephalosporins, but worse activity against methicillin-susceptible S.aureus. … [A215582] It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges[A215582], eyes[A215647], and inner ear[A215627].
Mixtures: CEF-3 INJECTION IM (250MG), ROCEPHIN VIAL 250MG IMProducts: Ceftriaxone and Dextrose, Rocephin Inj 10gm/vialChlorambucil
go.drugbank.com/drugs/DB00291ApprovedInvestigationalA nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases.
Categories: Antineoplastic and Immunomodulating AgentsProducts: Leukeran Tablets 2mgCanagliflozin
go.drugbank.com/drugs/DB08907ApprovedInvestigationalIt was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 for a second indication of reducing the risk of cardiovascular events in patients diagnosed with type … Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise
Mixtures: Vokanamet (Canagliflozin 150mg/ Metformin 500mg) Film-Coated Tablet, Vokanamet (Canagliflozin 150mg/ Metformin 850mg) Film-Coated TabletCategories: Alimentary Tract and Metabolism, metformin and canagliflozinAtropine
go.drugbank.com/drugs/DB00572ApprovedInvestigationalVet approvedAtropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active. … [A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosseous, endotracheal and ophthalmic methods.
Mixtures: Diphenoxylate Hcl and Atropine Sulfate, Diphenoxylate Hydrochloride and Atropine SulfateCategories: pralidoxime and atropine, Alimentary Tract and MetabolismCyclophosphamide
go.drugbank.com/drugs/DB00531ApprovedInvestigationalPrecursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. … Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Categories: Antineoplastic and Immunomodulating AgentsProducts: Cytoxan Tab 25mg, Procytox Tab 25mg