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Cocaine
go.drugbank.com/drugs/DB00907ApprovedIllicitInvestigationalIt is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat.
Clobazam
go.drugbank.com/drugs/DB00349ApprovedIllicitInvestigational[A256958] In 2005, clobazam also received approval from Health Canada as an add-on therapy for generalized tonic-clonic, myoclonic, and focal impaired awareness seizures.[A256978] … [A521,A522] In October 21, 2011, the FDA approved clobazam as an adjunctive treatment for seizures associated with Lennox-Gastaut syndrome in adults and children aged two years and older.
Amifostine
go.drugbank.com/drugs/DB01143ApprovedInvestigationalA phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
Categories: Detoxifying Agents for Antineoplastic TreatmentLymecycline
go.drugbank.com/drugs/DB00256ApprovedInvestigationalWithdrawnLymecycline is a broad-spectrum second-generation tetracycline antibiotic used for the treatment of acne and other susceptible bacterial infections.
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseZucapsaicin
go.drugbank.com/drugs/DB09120ApprovedWithdrawnZucapsaicin has also been evaluated for the management of several conditions manifested by chronic nerve pain.
Categories: Topical Products for Joint and Muscular PainEteplirsen
go.drugbank.com/drugs/DB06014ApprovedInvestigationalEteplirsen was the first treatment for DMD approved by the FDA.[A244925] … Eteplirsen was first approved by the FDA in September 2016 for the treatment of Duchenne muscular dystrophy (DMD) in patients with a confirmed mutation of the DMD gene, which codes for dystrophin, that
Cefroxadine
go.drugbank.com/drugs/DB11367ApprovedWithdrawnCefroxadine is an orally available cephalosporin antibiotic. As part of its drug class, it shares structural properties to cefalexin as well as its activity spectrum. It was used in Italy but has since been withdrawn.
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseVoretigene neparvovec
go.drugbank.com/drugs/DB13932ApprovedInvestigationalThis type of virus is vastly used as vectors for gene therapy because they can infect dividing and quiescent cell integrating just the carried genes into the host genome without fully integrating into … When used in genetic therapy, this virus is modified for the elimination of its negligible integrative capacity by the removal of *rep* and *cap* and the insertion of the desired gene with its promoter
Oxyphenonium
go.drugbank.com/drugs/DB00219ApprovedThe drug has also been used in the form of eye drops for mydriatic effect. [PubChem]
Categories: Drugs for Functional Gastrointestinal DisordersRegorafenib
go.drugbank.com/drugs/DB08896ApprovedInvestigationalIt is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012.