Cefroxadine is an orally available cephalosporin antibiotic. As part of its drug class, it shares structural properties to cefalexin as well as its activity spectrum. It was used in Italy... It was used in Italy but has since been withdrawn.
- Mechanism
- Curator reviewed · 1 reference
Cefrixadine is a cephalosporin antibiotic, a class of β-lactam antibiotics similar to penicillins, which binds to and inhibits penicillin binding proteins (PBPs). PBPs are responsible for catalyzing the transpeptidase reaction which cross-links the peptide side chains on the sugar residues of a peptidoglycan unit, adding the unit to the peptidoglycan layer. This disrupts the balance between the hydrolysis of peptidoglycan, in order to insert new peptidoglycan units, by murein hydrolase and the attachment of the new units which leads to overall destruction of the peptidoglycan layer. With the loss of its peptidoglycan layer the cell also loses its resistance to the high osmotic pressure inside its membrane and lyses.
- Primary indication
- Was used for the treatment of bacterial infections.Curator reviewed
- Formula / weight
- C16H19N3O5S · 365.4 g/mol (avg)
- Code names
- CGP-9000
Resolves to
RDMOROXKXONCAL-UEKVPHQBSA-NSMILES[H][C@]12SCC(OC)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)C1=CCC=CC1)C(O)=OWhat you can answer from here — as of March 06, 2025
Which drugs share a target with Cefroxadine, and which of those have an active Phase 3 trial?
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