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Anisotropine methylbromide
go.drugbank.com/drugs/DB00517ApprovedLarger doses are required to decrease motility of the gastrointestinal and urinary tracts and to inhibit gastric acid secretion. … Its use as treatment adjunct in peptic ulcer has been replaced by the use of more effective agents.
Fexinidazole
go.drugbank.com/drugs/DB12265ApprovedHuman African trypanosomiasis (HAT, also colloquially referred to as sleeping sickness), caused by _T. brucei gambiense_ and _T. brucei rhodesiense_, remains a moderate risk (>1/10,000 inhabitants per … Transmitted by the bite of an infected tsetse fly, HAT is biphasic with a first (hemolymphatic) stage that progresses to a second (meningoencephalitic) stage in which patients experience progressively
Rifaximin
go.drugbank.com/drugs/DB01220ApprovedInvestigationalIt is marketed under the brand name Xifaxan by Salix Pharmaceuticals. … It has multiple indications and is used in treatment of traveller's diarrhea caused by E. coli; reduction in risk of overt hepatic encephalopathy recurrence; as well as diarrhea-predominant irritable bowel
(S)-camphor
go.drugbank.com/drugs/DB11345ApprovedCamphor is a major active ingredient in over-the-counter balms and liniments supplied as topical analgesics by causing sensitization to heat and coolness to relieve minor muscle and joint pain [A33086] … (S)-camphor is not the naturally-occurring stereoisomer but displays similar TRPV channel affinity and current inhibition [A33086].
Zapomeran
go.drugbank.com/drugs/DB21761ApprovedSelf-amplification allows for the use of lower doses while providing higher immunogenicity compared to a conventional mRNA COVID-19 vaccine. … [L52580,L52390] The self-amplifying nature of the vaccine is due to the mRNA additionally encoding a replicase enzyme, which creates more copies of the mRNA itself once inside the cell.
Enmetazobactam
go.drugbank.com/drugs/DB18716ApprovedInvestigational[L50126] Enmetazobactam is used as cefepime-sparing therapy by preventing its breakdown by ESBL. … [A263276] The combination product of enmetazobactam and [cefepime] was first approved by the FDA on February 23, 2024, for the treatment of complicated urinary tract infections.
Ventilator Associated Bacterial Pneumonia (VABP)
go.drugbank.com/conditions/DBCOND0149717Synonyms: Pneumonia due to bacteria NOS (disorder)Gelatin
go.drugbank.com/drugs/DB11242ApprovedInvestigationalVet approvedWithdrawn[A32426] Gelatin is generally recognized as safe (GRAS) by the FDA to be a non-hazardous food or food ingredient. … Gelatin continues to be approved for other routes of administration.[L43942]
Fish oil
go.drugbank.com/drugs/DB13961ApprovedInvestigationalNutraceuticalIn general, dietary or pharmaceutical intake of these acids is primarily the only way to increase their levels in the human body where they are overall an essential element to dietary health as they have … Regardless, the specific mechanisms of action for these effects have yet to be formally elucidated.
Mixtures: TL-Care DHA, TL-Select DHAAzathioprine
go.drugbank.com/drugs/DB00993ApprovedInvestigationalAzathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic … [A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection.