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Aflibercept
go.drugbank.com/drugs/DB08885ApprovedInvestigational[L47976] An aflibercept biosimilar, Yesafili, was approved for use in the EU in September 2023. … [A261281,A261286] Due to the 2 fused VEGFR, aflibercept has a higher affinity to the cognate ligands than the endogenous individual receptor.
Products: EYLEA SOLUTION FOR INJECTION IN VIAL 2MG, EYLEA 40MG/ML SOLUTION FOR INJECTION IN VIALInterferon alfa-2b
go.drugbank.com/drugs/DB00105ApprovedInvestigationalInterferon alpha 2b (human leukocyte clone hif-sn 206 protein moiety reduced). A type I interferon consisting of 165 amino acid residues with arginine in position 23. … It is used extensively as an antiviral or antineoplastic agent.
Mixtures: Rebetron Solution (albumin (human) Free) (18 Miu Multi-dose Pen / 200mg Capsules), Rebetron Ready To Use Solution (albumin(human)free) (6000000 Iu/ml and 200mg Capsules)Products: VIRAFERON INYECTABLE 3 MILLONES IU, INTRON A MULTIDOSE PEN 30 miu/penLiraglutide
go.drugbank.com/drugs/DB06655ApprovedInvestigational[A6932] Liraglutide was granted FDA approval on January 25, 2010.[L6070] … [A6932] Liraglutide is made by attaching a C-16 fatty acid (palmitic acid) with a glutamic acid spacer on the remaining lysine residue at position 26 of the peptide precursor.
Synonyms: Arg34Lys26-(N-ε-(γ-Glu(N-α-hexadecanoyl)))-GLP-1[7-37], N²⁶-(N-Hexadecanoyl-L-gamma-glutamyl)-[34-L-arginine]glucagon-like peptide 1-(7-37)-peptideMixtures: Xultophy Pre-filled PenMethadone
go.drugbank.com/drugs/DB00333ApprovedInvestigationalMethadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. … [A185888,A185891,A185897] Compared with [morphine], the gold standard reference opioid, methadone also acts as an agonist of κ- and σ-opioid receptors, as an antagonist of the N-methyl-D-aspartate (NMDA
Synonyms: dl-MethadoneCategories: Drugs Used in Opioid Dependence, Drugs Used in Addictive DisordersN-acetyltyrosine
go.drugbank.com/drugs/DB11102ApprovedInvestigationalN-acetyltyrosine is administered as parenteral nutrition or intravenous infusion due to its enhanced solubility compared to tyrosine [A32652]. … N-acetyltyrosine, also referred to as N-acetyl-L-tyrosine, is used in place of as a tyrosine precursor. [DB00135] is a non-essential amino acid with a polar side group.
Synonyms: N-acetyltyrosin, N-acetyltyrosineMixtures: AMINOPLASMAL-5% E INFUSION, AMINOPLASMAL-10% E INFUSIONOxytocin
go.drugbank.com/drugs/DB00107ApprovedInvestigationalVet approved[A229008,A228593] In the mid-1950s, synthetic oxytocin was successfully synthesized by a biochemist named Vincent du Vigneaud; he was later recognized with a Nobel prize for his work. … [A229008] It plays an important role in pair bonding, social cognition and functioning, and even fear conditioning.
Products: Oxyla 10 IU/mL Injection, SYNTOCINON INJECTION 10 iu/mlMilrinone
go.drugbank.com/drugs/DB00235ApprovedInvestigationalmetabolites, resulting in complex systemic pathologies. … [A228333] As a PDE-III inhibitor, milrinone results in increased cAMP levels and improves cardiac function and peripheral vasodilation in acute decongested heart failure.
Mixtures: Milrinone Lactate in DextroseCategories: Compounds used in a research, industrial, or household settingThiethylperazine
go.drugbank.com/drugs/DB00372ApprovedInvestigationalWithdrawnA dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins.
Categories: Dopamine D2 Receptor AntagonistsCyclandelate
go.drugbank.com/drugs/DB04838ApprovedWithdrawnCyclandelate is not approved for use in the U.S. or Canada, but is approved in various European countries.
Conjugated estrogens
go.drugbank.com/drugs/DB00286ApprovedInvestigational[T475] The conjugated estrogen mixture was approved for marketing in US in 1942 based on the efficacy against certain conditions. … Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.