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Displaying results 1301 - 1310 of 5758 in total
  1. Target

    Deacylase AADAC

    go.drugbank.com/bio_entities/BE0010087
    EnzymeHumans

    Catalyzes the hydrolysis of ester and amide bonds and is largely involved in prodrugs activation, xenobiotic detoxification or toxicity, and, in some contexts, lipid and indole metabolism (PubMed:17936933, PubMed:18034159, PubMed:1933937...

    Synonyms: DAC
  2. Drug

    Medrysone

    go.drugbank.com/drugs/DB00253
    Approved

    Medrysone is a corticosteroid used in ophthalmology.

    Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates
  3. Drug

    Polythiazide

    go.drugbank.com/drugs/DB01324
    Approved

    A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826)

  4. Drug

    Vorinostat

    go.drugbank.com/drugs/DB02546
    ApprovedInvestigational

    Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA), is a drug currently under investigation for the treatment of cutaneous T cell lymphoma (CTCL), a type of skin cancer, to be used when the disease persists, gets worse, or comes...

  5. Drug

    Exemestane

    go.drugbank.com/drugs/DB00990
    ApprovedInvestigational

    Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the ...

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  6. Target

    4,4'-diapophytoene synthase

    go.drugbank.com/bio_entities/BE0003866
    TargetStaphylococcus aureus

    Involved in the biosynthesis of the yellow-orange carotenoid staphyloxanthin, which plays a role in the virulence via its protective function against oxidative stress. Catalyzes the head-to-head condensation of two molecules of farnesyl ...

    Synonyms: DAP synthase
  7. Drug

    PR-104

    go.drugbank.com/drugs/DB05968
    Investigational

  8. Drug

    TMC-310911

    go.drugbank.com/drugs/DB15623
    Investigational

    both treatment-naive and PI-experienced patients. … TMC-310911 (also known as ASC-09) is a novel investigational protease inhibitor (PI) that is structurally similar to the currently available [darunavir].

  9. Drug

    Toremifene

    go.drugbank.com/drugs/DB00539
    ApprovedInvestigational

    Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like tamoxifen, toremifene is part of the first-generation triphenylethylene derivative ...

    Categories: P-glycoprotein inhibitors, P-glycoprotein substrates
  10. Drug

    Tinlorafenib

    go.drugbank.com/drugs/DB17082
    Investigational

    Tinlorafenib (PF-07284890) is a potent, selective, highly brain-penetrant, small-molecule inhibitor of BRAF V600 mutations.[A253992]