Polythiazide is a thiazide diuretic used in the management of hypertension and treatment of edema. A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide.
- Mechanism
- Curator reviewed
As a diuretic, polythiazide inhibits active chloride reabsorption at the early distal tubule via the thiazide-sensitive Na-Cl cotransporter (TSC), resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like polythiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of polythiazide may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.
- Primary indication
- Polythiazide is a thiazide diuretic used to decrease edema and decrease blood pressure.Curator reviewed · 9 structured indications
- Formula / weight
- C11H13ClF3N3O4S3 · 439.882 g/mol (avg)
- First approval
- United States, 2005
- Brand names
Resolves to
CYLWJCABXYDINA-UHFFFAOYSA-NSMILESCN1C(CSCC(F)(F)F)NC2=CC(Cl)=C(C=C2S1(=O)=O)S(N)(=O)=OWhat you can answer from here — as of September 13, 2026
Which drugs share a target with Polythiazide, and which of those have an active Phase 3 trial?
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