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Chlorphentermine
go.drugbank.com/drugs/DB01556ApprovedIllicitWithdrawnA sympathomimetic agent that was formerly used as an anorectic. It has properties similar to those of dextroamphetamine. It has been implicated in lipid storage disorders and pulmonary hypertension.
Synonyms: a,a-Dimethyl-p-chlorophenethylamineMedrogestone
go.drugbank.com/drugs/DB09124ApprovedWithdrawnIt was conceived as an alternative for an orally effective contraceptive option.[A31526] It was developed by Ayerst, approved in Canada in 1969 and its current status is cancelled post-marketing.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesDoxercalciferol
go.drugbank.com/drugs/DB06410ApprovedInvestigationalD2. … Doxercalciferol is a synthetic vitamin D2 analog that undergoes metabolic activation in vivo to form 1α,25-dihydroxyvitamin D2 (1α,25-(OH)2D2), a naturally occurring, biologically active form of vitamin
Synonyms: 1-Hydroxyvitamin D2, 1α-hydroxyvitamin D2Categories: Vitamin D and AnaloguesAlizapride
go.drugbank.com/drugs/DB01425InvestigationalAlizapride is a dopamine antagonist that is capable of demonstrating both prokinetic and antiemetic effects. This kind of pharmacological activity makes it effective for use in the treatment of various kinds of nausea and vomiting, inclu...
Categories: Dopamine D2 Receptor AntagonistsZuranolone
go.drugbank.com/drugs/DB15490ApprovedInvestigationalUnlike other more common GABA<sub>A</sub> positive allosteric modulators on the market like benzodiazepines, zuranolone can modulate both synaptic and extrasynaptic GABA<sub>A</sub> conductance due to … [A260776,A260786] Zuranolone was designed with a pharmacological profile of a neuroactive steroid in mind while also possessing a pharmacokinetics profile of an oral, once-daily dosing formulation.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesElvitegravir
go.drugbank.com/drugs/DB09101ApprovedInvestigationalAlthough available as a single dose tablet, elvitegravir must be used in combination with an HIV protease inhibitor coadministered with ritonavir and another antiretroviral drug.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 InducersSilver
go.drugbank.com/drugs/DB12965ApprovedInvestigationalSilver nanoparticles especially have been widely used in industrial, household, and healthcare-related products due to their potent antimicrobial activity. … Silver and its compounds have been used in trials studying the management of dental caries since the 1800s, and they may be found in dental pastes as an active ingredients.
Products: Yan Plus Super MedicDebrisoquine
go.drugbank.com/drugs/DB04840ApprovedAn adrenergic neuron-blocking drug similar in effects to guanethidine. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesPralatrexate
go.drugbank.com/drugs/DB06813ApprovedInvestigationalPralatrexate is an antifolate for the treatment of relapsed or refractory peripheral T-cell lymphoma [L37674]. … Pralatrexate was developed in response due to the inferior responses of patients using the standard therapy for their B-cells counterparts.