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Displaying results 1301 - 1310 of 10000 in total
  1. Drug

    Osimertinib

    go.drugbank.com/drugs/DB09330
    ApprovedInvestigational

    Approximately 10% of patients with NSCLC have a rapid and clinically effective response to EGFR-TKIs due to the presence of specific activating EGFR mutations within the tumour cells. … In contrast, third-generation inhibitors are specific for the gate-keeper T790M mutations which increases ATP binding activity to EGFR and result in poor prognosis for late-stage disease.

    Synonyms: N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamideProducts: TAGRISSO® 40 MG, TAGRISSO® 80 MG.
  2. Drug

    Methotrimeprazine

    go.drugbank.com/drugs/DB01403
    Approved

    (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)

    Synonyms: (-)-(2R)-3-(2-methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethylpropan-1-amineCategories: Dopamine D2 Receptor Antagonists
  3. Drug

    DTS-201

    go.drugbank.com/drugs/DB06071
    Experimental

    DTS-201 is a prodrug of doxorubicin, a widely used anti-cancer drug that Diatos intends to develop for the treatment of various solid tumors. It is activated in the tumor environment. … DTS-201 may be suitable for the treatment of many types of solid tumors, including tumors sensitive to doxorubicin and potentially other tumors which are not currently treated with doxorubicin but which

  4. Drug

    Neomycin

    go.drugbank.com/drugs/DB00994
    ApprovedInvestigationalVet approved

    [A191529] Neomycin sulfate as monotherapy is available in an oral solution for adjunct use in the treatment of hepatic coma. … [L10532] Neomycin is also used in combination with [polymyxin B] sulfates and [dexamethasone] in ophthalmic preparations for use in the treatment of inflammatory conditions and infections in the eye.

    Mixtures: THIOCILLINE 500 IU/G + 5 MG/G DERİ MERHEMİ, 30 G, THIOCILLINE 500 IU/G + 5 MG/G GÖZ MERHEMİ, 5 GRProducts: Neomycin 528.5 mg/g Water Soluble Powder, Pomada de Sulfa
  5. Target

    Homeobox protein engrailed-2

    go.drugbank.com/bio_entities/BE0004484
    TargetHumans

    Synonyms: Hu-En-2, Homeobox protein en-2
  6. Drug

    Sulbutiamine

    go.drugbank.com/drugs/DB13416
    Investigational

    The chronic administration of the drug has demonstrated to improve long term memory formation in mice. … While its other uses include improvement of erectile dysfunction and reduction of psycho-behavioural inhibition, sulbutiamine showed evidence of modulatory effect on dopaminergic and glutamatergic cortical

    Products: ARCALION TABLET 200 MG, SULBUTIAMINA 200 MG.
  7. Drug

    Chondroitin sulfate

    go.drugbank.com/drugs/DB09301
    ApprovedInvestigationalNutraceutical

    Chondroitin sulfate is composed of alternating 1,3-N-acetyl-β-d-galactosamine and 1,4-β-d-glucuronic acid units which bear 4-O- and/or 6-O-sulfations at the N-acetylgalactosamine units disposed of in specific … [A32063] Chondroitin sulfate is sold as an OTC dietary supplement in North America and it is a prescription drug under the EMA in Europe.[A32066]

    Mixtures: Cartifit 200 mg/250 mg Hartkapseln, DONA PLUS 750 MG + 600 MG SAŞE, 20 ADETProducts: Cartexan 400 mg Hartkapseln, Condrosulf 400 mg - Kapseln
  8. Drug

    Trifluoperazine

    go.drugbank.com/drugs/DB00831
    Approved

    It is used as an antipsychotic and an antiemetic.

    Mixtures: CUAIT - D COMPRIMIDOS.Categories: Dopamine D2 Receptor Antagonists
  9. Drug

    Warfarin

    go.drugbank.com/drugs/DB00682
    ApprovedInvestigational

    Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. … Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration.

    Categories: Compounds used in a research, industrial, or household settingProducts: VARFARİN 5 MG TABLET, 20 ADET, Nu-warfarin
  10. Drug

    Ambrisentan

    go.drugbank.com/drugs/DB06403
    ApprovedInvestigational

    In addition, it is approved in the United States for use in combination with tadalafil to reduce the risks of disease progression, hospitalization and to improve exercise ability. … As an endothelin receptor antagonist, Ambrisentan prevents endogenous endothelin peptide from constricting the muscles in blood vessels, allowing them to relax and permit a reduction in blood pressure.

    Products: AMBRISENTAN DR. REDDY?S, INFINIX® 5 MG