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Ribociclib
go.drugbank.com/drugs/DB11730ApprovedInvestigationalThese proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Ribociclib was approved by the FDA in March 2017 under the brand name Kisqali.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsClodronic acid
go.drugbank.com/drugs/DB00720ApprovedInvestigationalVet approved[A1923] clodronate’s use has decreased over the years in favor of the third generation, nitrogen containing bisphosphonate [zoledronic acid], [ibandronic acid], [minodronic acid], and [risedronic acid]
Valdecoxib
go.drugbank.com/drugs/DB00580ApprovedWithdrawnValdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesEpinephrine
go.drugbank.com/drugs/DB00668ApprovedInvestigationalVet approvedMany new products/biosimilars and dosage routes have been approved under various names over the last several decades [L4355], [L4356], [L4358].
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP2C9 InhibitorsAlanine
go.drugbank.com/drugs/DB00160ApprovedInvestigationalNutraceuticalAlanine is a non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases immunity, and provides energy for muscle...
Mixtures: Aminosyn-PF, Aminosyn-PFProline
go.drugbank.com/drugs/DB00172ApprovedInvestigationalNutraceuticalProline is one of the twenty amino acids used in living organisms as the building blocks of proteins. Proline is sometimes called an imino acid, although the IUPAC definition of an imine requires a carbon-nitrogen double bond. Proline is...
Synonyms: PMixtures: Aminosyn-PF, Aminosyn-PFTobramycin
go.drugbank.com/drugs/DB00684ApprovedInvestigationalAminoglycosides, many of which are derived directly from Streptomyces spp., are concentration-dependent bactericidal antibiotics with a broad spectrum of activity against Gram-positive and Gram-negative organisms. Inhaled tobramycin is n...
Tegaserod
go.drugbank.com/drugs/DB01079ApprovedWithdrawn[L5918,F4229] It was, however, voluntarily withdrawn from widespread use in the US market in 2007 after concerns arose over the possibility that tegaserod could potentially cause dangerous cardiovascular … [F4226] Despite the relative complications involved in its history of regulatory approval, ever since its first introduction in 2002 tegaserod remains the only therapy for IBS-C that possesses the unique
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesFidaxomicin
go.drugbank.com/drugs/DB08874ApprovedInvestigational[A190516] The FDA initially approved fidaxomicin in May 2011 for the treatment of _C. difficile_-associated diarrhea in adult patients over the age of 18. … Fidaxomicin is a novel macrolide antibiotic used in the treatment of diarrhea caused by _Clostridioides_ (formerly _Clostridium_) _difficile_ in adult and pediatric patients over the age of 6 months.
Categories: P-glycoprotein substrates, Cytochrome P-450 CYP3A InhibitorsLabetalol
go.drugbank.com/drugs/DB00598ApprovedInvestigationalLabetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. Labetalol is formulated as an injection or tablets to treat hypertension. Labetalol was granted FDA approval on 1 A...
Categories: Cytochrome P-450 Substrates, Adrenergic alpha-1 Receptor Antagonists