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Collagenase clostridium histolyticum
go.drugbank.com/drugs/DB00048ApprovedInvestigational[L14912] On July 6, 2020 a combination of injectable bacterial collagenases was approved by the FDA for the treatment of cellulite in adult women. … [L14882] The topical formulation is used for the debridement of necrotic tissue due to burns or chronic ulcers.
Categories: Preparations for Treatment of Wounds and UlcersEteplirsen
go.drugbank.com/drugs/DB06014ApprovedInvestigational[A244930] It is caused by loss-of-function mutations in the DMD gene coding for dystrophin, an essential protein involved in maintaining the structural integrity and function of muscle fibres. … Eteplirsen was first approved by the FDA in September 2016 for the treatment of Duchenne muscular dystrophy (DMD) in patients with a confirmed mutation of the DMD gene, which codes for dystrophin, that
Synonyms: (P-deoxy-P-(dimethylamino)](2',3'-dideoxy-2',3'-imino-2',3'-seco)(2'a→5')(C-m5U-C-C-A-A-C-A-m5U-C-A-A-G-G-A-A-G-A-m5U-G-G-C-A-m5U-m5U-m5U-C-m5U-A-G),5'-(P-(4-((2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)carbonylCategories: Compounds used in a research, industrial, or household settingPhenol
go.drugbank.com/drugs/DB03255ApprovedInvestigationalPhenol is also used as an oral analgesic or anesthetic in products such as Chloraseptic to treat pharyngitis. … It is active against a wide range of micro-organisms including some fungi and viruses, but is only slowly effective against spores. Phenol has been used to disinfect skin and to relieve itching.
Mixtures: DİŞİNOL 2 G + 0,5 G + 3,5 G/10 ML ÇÖZELTİ, Absorbine Jr Pro No Mess Roll-on PlusCategories: Compounds used in a research, industrial, or household settingDelamanid
go.drugbank.com/drugs/DB11637ApprovedInvestigationalDelamanid is an anti-tuberculosis agent derived from the nitro-dihydro-imidazooxazole class of compounds that inhibits mycolic acid synthesis of bacterial cell wall [A31965]. … Spontaneous resistance to delamanid was observed during treatment, where mutation in one of the 5 F420 coenzymes responsible for bioactivation of delamanid contributes to this effect [L1407].
Categories: Drugs for Treatment of TuberculosisProducts: Deltyba Film-Coated Tablets 50 mg, DELTYBA 50 MG FLİM TABLET, 40 ADETCalcium and integrin-binding protein 1
go.drugbank.com/bio_entities/BE0008691TargetHumansCalcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Inv...
Synonyms: SNK-interacting protein 2-28Ergocalciferol
go.drugbank.com/drugs/DB00153ApprovedInvestigationalNutraceutical[T577] The production of ergocalciferol was prompted by the identification of dietary deficiency, more specifically vitamin D, as the main causative factor for the development of rickets. … [A177526] It is synthesized by some plants in the presence of UVB light.
Synonyms: (3β,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol, (5Z,7E,22E)-(3S)-9,10-seco-5,7,10(19),22-ergostatetraen-3-olMixtures: Calcium Mg and Zn Capsules With Vitamin DMoxetumomab pasudotox
go.drugbank.com/drugs/DB12688ApprovedInvestigationalThe predecessor of Moxetumab pasudotox (MxP), named BL22, was first created based on the antibody RFB4 which specifically binds to CD22. … [A38864] It was developed by Astra Zeneca and FDA approved on September 13, 2018, after being granted the status of Fast Track, Priority Review and Orphan Drug designations.[L4568]
Categories: CD22 (Clusters of Differentiation 22) inhibitorsCefiderocol
go.drugbank.com/drugs/DB14879ApprovedInvestigational[A189150] A concern noted in the trial was a 0.3% higher rate of all cause mortality, the cause of which has not been determined. … [FDA Label] This indication was supported by a positive clinical trial composed of 448 patients with complicated urinary tract infections which demonstrated a 72.6% rate of symptom resolution and bacterial
Categories: Compounds used in a research, industrial, or household settingNalbuphine
go.drugbank.com/drugs/DB00844ApprovedInvestigationalIt appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors.
Categories: Heterocyclic Compounds with 4 or More Rings, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProducts: Nubain 10 mg/ml Injektionslösung, NALBUFINA CLORHIDRATO 10 MG/ML.Multipotent adult arogenitor cells
go.drugbank.com/drugs/DB15742InvestigationalThe cells for creation of the product are isolated from a qualified donor and expanded on a large scale and then frozen until use. After administration, the cells are cleared from the body over time. … Additional benefits of MultiStem include their low immunogenicity, meaning they can be administered without tissue matching or concurrent immunosuppressive agents.