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Anagrelide
go.drugbank.com/drugs/DB00261ApprovedInvestigational[L14153] It is an oral imidazoquinazoline that was first approved for use in the US in 1997.[A214274] It appears to carry a better response rate than other thrombocythemia treatments (e.g. … Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms.
Osilodrostat
go.drugbank.com/drugs/DB11837ApprovedInvestigationalCushing's disease),[A191850] and was granted FDA approval and Orphan Drug designation in the US in March 2020 for the same indication.[L12162] … [A191910] As an orally bioavailable drug therapy, osilodrostat provides a novel treatment option for patients in whom removal of the causative tumor is not an option or for whom previous pituitary surgery
Upadacitinib
go.drugbank.com/drugs/DB15091ApprovedInvestigational[A189165] Despite a variety of therapeutic agents available for treatment, up to 40% of the patients do not respond to current therapies, including biological therapies. … Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression.
Udenafil
go.drugbank.com/drugs/DB06267ApprovedIt is not yet approved for use in the U.S., E.U., or Canada. … Udenafil is a new phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction (ED). It has been approved in South Korea and will be marketed under the brand name Zydena.
Categories: Drugs Used in Erectile DysfunctionIodide I-123
go.drugbank.com/drugs/DB09420ApprovedInvestigationalFollowing oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. … Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease.
Synonyms: I 123, I-123Salts: Sodium iodide I-123Erlotinib
go.drugbank.com/drugs/DB00530ApprovedInvestigationalRecent studies demonstrate that erlotinib is also a potent inhibitor of JAK2V617F, which is a mutant form of tyrosine kinase JAK2 found in most patients with polycythemia vera (PV) and a substantial proportion … Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer
Categories: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitorsButobarbital
go.drugbank.com/drugs/DB01353ApprovedIllicitButobarbital is a sedative and a hypnotic drug.
rhThrombin
go.drugbank.com/drugs/DB04923ApprovedWithdrawnThe production of recombinant proteins is not dependent on the availability of blood from animals or human donors and can be scaled-up to meet market demand. … Thrombin is used in more than 1 million surgeries each year in the United States. Currently, only thrombin derived from bovine blood is available in the U.S. as a stand-alone thrombin product.
Belinostat
go.drugbank.com/drugs/DB05015ApprovedInvestigationalIt was US-approved in July 2014 as a therapeutic agent for relapsed or refractory peripheral T-cell lymphoma. … It was developed as an orphan drug to target hematological malignancies and solid tumors by TopoTarget.
Pepsin
go.drugbank.com/drugs/DB13198ApprovedWithdrawnInterestingly, recent research has suggested that pepsin participates in the digestion of nucleic acids [L2391]. … Pepsin is a potent enzyme in gastric juice that digests proteins such as those in meat, eggs, seeds, and dairy products [L2358].