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Displaying results 131 - 140 of 134502 in total
  1. Pathway

    Pantoprazole Action Pathway

    smpdb.ca/view/SMP0123293
    Drug action

    In parietal cells, carbonic anhydrase converts water and carbon dioxide to hydrogen bicarbonate ions and H+. … The H+/K+ ATPase is located on the apical membrane and pumps the H+ from the cell into the stomach lumen and K+ from the lumen into the cell.

    Drugs: Pantoprazole · Potassium cation · Zinc
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  2. Pathway

    Kidney Function - Distal Convoluted Tubule

    smpdb.ca/view/SMP0121012
    Physiological

    In addition, sodium, chlorine, and calcium are also reabsorbed back into the systemic circulation via their respective channels and exchangers. … As a result, a high concentration of sodium, chlorine, and calcium in the blood vessels occurs. The reabsorption of ions and water increases blood fluid volume and blood pressure.

    Drugs: Potassium cation · Calcium · Urea
    Enzymes: Sodium/calcium exchanger 1, Sodium/potassium-transporting ATPase subunit alpha-1
  3. Pathway

    Omeprazole Action Pathway

    smpdb.ca/view/SMP0122674
    Drug action

    In parietal cells, carbonic anhydrase converts water and carbon dioxide to hydrogen bicarbonate ions and H+. … The H+/K+ ATPase is located on the apical membrane and pumps the H+ from the cell into the stomach lumen and K+ from the lumen into the cell.

    Drugs: Omeprazole · Potassium cation · Zinc
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  4. Pathway

    Esomeprazole Action Pathway

    smpdb.ca/view/SMP0123196
    Drug action

    In parietal cells, carbonic anhydrase converts water and carbon dioxide to hydrogen bicarbonate ions and H+. … The H+/K+ ATPase is located on the apical membrane and pumps the H+ from the cell into the stomach lumen and K+ from the lumen into the cell.

    Drugs: Esomeprazole · Potassium cation · Zinc
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  5. Pathway

    Lansoprazole Action Pathway

    smpdb.ca/view/SMP0123261
    Drug action

    In parietal cells, carbonic anhydrase converts water and carbon dioxide to hydrogen bicarbonate ions and H+. … The H+/K+ ATPase is located on the apical membrane and pumps the H+ from the cell into the stomach lumen and K+ from the lumen into the cell.

    Drugs: Lansoprazole · Potassium cation · Zinc
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  6. Pathway

    Bumetanide Diruretic Action Pathway

    smpdb.ca/view/SMP0124517
    Drug action

    Bumetanide binds to NKCC2 transporter and inhibits it, preventing Na+, K+ and Cl- reabsorption from the lumen. … The K+/Cl- co-transporter moves K+ and Cl- from the cell into the peritubular fluid and the Cl- channel transports Cl- from the cell into the peritubular fluid.

    Drugs: Bumetanide · Potassium cation
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  7. Pathway

    Rabeprazole Antacid Action Pathway

    smpdb.ca/view/SMP0123294
    Drug action

    In parietal cells, carbonic anhydrase converts water and carbon dioxide to hydrogen bicarbonate ions and H+. … The H+/K+ ATPase is located on the apical membrane and pumps the H+ from the cell into the stomach lumen and K+ from the lumen into the cell.

    Drugs: Rabeprazole · Potassium cation · Zinc
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  8. Pathway

    Furosemide Diuretic Action Pathway

    smpdb.ca/view/SMP0122712
    Drug action

    This is relieves symptoms such as swelling/ edema and hypertension in patients. Furosemide may also inhibit sodium and chloride reabsorption in the proximal and distal tubules. … It binds to this transporter, inhibiting it and preventing Na+, K+ and Cl- reabsorption from the lumen.

    Drugs: Furosemide · Potassium cation
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  9. Pathway

    Desipramine Metabolism Pathway

    smpdb.ca/view/SMP0000626
    Drug metabolism

    It does so by competing for the same binding site as norepinephrine on the sodium-dependent noradraneline transporter (SLC6A2) and by competing with serotonin for binding to the sodium-dependent serotonin … This increases the concentrations of both norepinephrine and serotonin in their respective synapses and reverses the state of low concentrations of both neurotransmitters found in depression.

    Drugs: Desipramine · Mesoheme
    Enzymes: Sodium-dependent serotonin transporter, Sodium-dependent noradrenaline transporter
  10. Pathway

    Kidney Function - Ascending Limb of The Loop of Henle

    smpdb.ca/view/SMP0121010
    Physiological

    Chloride, potassium, and sodium are co-transported across the apical membrane (closest to the lumen) via transporters from the filtrate. … The loop of Henle of the nephron can be separated into an ascending limb and the descending limb. The descending limb is highly impermeable to solutes such as sodium, but permeable to water.

    Drugs: Potassium cation · Urea
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1