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Coagulation Factor IX (Recombinant)
go.drugbank.com/drugs/DB00100ApprovedIt is not derived from human blood (unlike human Factor IX complex), and is instead produced by a genetically engineered Chinese hamster ovary (CHO) cell line that secretes recombinant Factor IX into cell … Recombinant Coagulation Factor IX is a purified Factor IX glycoprotein produced by recombinant DNA technology.
Products: OCTANINE® F 500 UI, BENEFIX® 1000 UITuroctocog alfa pegol
go.drugbank.com/drugs/DB14738ApprovedInvestigationalIt was developed by Novo Nordisk and approved by the US FDA on October 16, 2013 [L1104]. … Novo Nordisk's brand name Esperoct (turoctocog alfa pegol, N8-GP) was approved by the US FDA on February 19, 2019.
Synonyms: N8-GP, Turoctocog alfa pegol, N8-GPProducts: ESPEROCT® 1500 UI, ESPEROCT® 2000 UIEfmoroctocog alfa
go.drugbank.com/drugs/DB11607ApprovedInvestigationalVIII, but does not contain the B-domain, which has no known biological function, and [DB13192], which is purified endogenous Factor VIII from human pooled blood and contains both A- and B-subunits. … Other drug products with similar structure and function to Efmoroctocog alfa include [DB13999], which is produced by recombinant DNA technology and is identical in sequence to endogenously produced Factor
Products: ELOCTATE® 250 UI, ELOCTATE® 500 UILimited or no alternative treatment options
go.drugbank.com/conditions/DBCOND0156255Drugs: Avibactam · Aztreonam · Metronidazole · Rezafungin · Sulopenem etzadroxil · Tebipenem pivoxil +2 moreSynonyms: Limited or no alternative treatment optionsNo history of Factor IX inhibitors
go.drugbank.com/conditions/DBCOND0155586Synonyms: No history of Factor IX inhibitorsTuroctocog alfa
go.drugbank.com/drugs/DB09109Approved[A31504] It was developped by Novo Nordisk and FDA approved in October 16, 2013.[L1104] … Turoctocog alfa is a recombinant factor VIII (rFVIII) with a truncated B-domain made from the sequence coding for 10 amino acids from the N-terminus and 11 amino acids from the C-terminus of the naturally
Products: NOVOEIGHT®1000 UI POLVO Y SOLVENTE PARA SOLUCIÓN INYECTABLE, NOVOEIGHT® 250 UI POLVO Y SOLVENTE PARA SOLUCIÓN INYECTABLEHuman thrombin
go.drugbank.com/drugs/DB11571ApprovedInvestigationalFurthermore, human thrombin is manufactured by chromatographic purification of prothrombin from cryo-poor plasma followed by activation with calcium chloride [FDA Label]. … Thrombin is a highly specific serine protease encoded by the F2 gene that transforms soluble fibrinogen into insoluble fibrin.
Products: THROMBIRAAS1000 UIIndomethacin
go.drugbank.com/drugs/DB00328ApprovedInvestigationalIntravenous indometacin is administered to close a hemodynamically significant patent ductus arteriosus, as indicated by clinical evidence, in premature infants. … Indometacin was first discovered in 1963 and it was first approved for use in the U.S. by the Food and Drug Administration in 1965, [A486] along with other acetic acid derivatives such as [diclofenac]
International brands: Nu-IndoCategories: Anti-Inflammatory Agents, Non-Steroidal (Non-Selective), Analgesics, Non-NarcoticNeomycin
go.drugbank.com/drugs/DB00994ApprovedInvestigationalVet approved[A175042] Neomycin is active against both gram-positive and gram-negative organisms and mediates its pharmacological action by binding to bacterial ribosomes and inhibiting protein synthesis, which is … also used in combination with [polymyxin B] sulfates and [hydrocortisone] in otic suspensions for use in the treatment of bacterial infections in the external auditory canal, including infections caused by
Mixtures: Bus and Classroom Yellow, Care Bus and Classroom YellowInternational brands: Neo-RxTrimipramine
go.drugbank.com/drugs/DB00726ApprovedInvestigationalTricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties.
Synonyms: 10,11-dihydro-N,N,β-trimethyl-5H-dibenz[b,f]azepine-5-propanamineCategories: Non-Selective Monoamine Reuptake Inhibitors, Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome