Astrocytoma (DBCOND0017186)

Identifiers

Synonyms
Astrocytomas / Astrocytic Tumors / Astrocytoma (morphologic abnormality)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Carmustine
An alkylating agent used in the treatment of various malignancies, including brain tumours and multiple myeloma, among others.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT02731521
Clinical Development of MR Spectroscopy and Imaging in Brain CancersNo drug interventionsNot AvailableNot Availablecompleted
NCT00897377
Treatment Strategy for Low-grade Gliomastreatment3terminated
NCT02388659
Clinical Development of Cancer-Specific MRS Biomarkers in Malignant GliomasNo drug interventionsNot AvailableNot Availablecompleted
NCT01655927
Efficacy of Tranexamic Acid in Brain Tumor Resectionstreatment3unknown_status
NCT05561374
Study of Safety and Pharmacokinetic Properties of Oral OKN-007 in Patients with Recurrent High-Grade Gliomatreatment1active_not_recruiting
NCT06620926
Impact of IDH Mutation and Adjuvant Chemo(radio)therapy on Survival Outcome in Grade II/III AstrocytomaNo drug interventionsNot AvailableNot Availablecompleted
NCT05484622
Study of Vorasidenib and Pembrolizumab Combination in Recurrent or Progressive Enhancing IDH-1 Mutant Gliomatreatment1recruiting
NCT06344130
Hypofractionation Trial of Re-irradiation in Good Prognosis Recurrent GlioblastomaNo drug interventionstreatment1recruiting
NCT06614855
A Phase IB 2 Dose Trial of IRS-1 HSV C134 (IND 17296) Administered Intratumorally in Patients With Recurrent Malignant GliomaNo drug interventionstreatment1not_yet_recruiting
NCT02942264
Zotiraciclib (TG02) Plus Dose-Dense or Metronomic Temozolomide Followed by Randomized Phase II Trial of Zotiraciclib (TG02) Plus Temozolomide Versus Temozolomide Alone in Adults With Recurrent Anaplastic Astrocytoma and Glioblastomatreatment1 / 2completed
NCT03115164
Astrocytoma / Desmoplastic Gamliogliomes (DIA / DIG) - Study of the French Cohort of the Last 20 Years : Clinical, Anatomopathological, Molecular and Radiological CharactersicsNo drug interventionsNot AvailableNot Availableunknown_status
NCT05345002
All-Trans Retinoic Acid (ATRA) Plus PD-1 Inhibition in Recurrent IDH-Mutant Gliomatreatment2recruiting
NCT02903784
Neural Basis of Language ProcessingNo drug interventionsotherNot Availablecompleted
NCT03538587
Feasibility and Preliminary Efficacy of a Mindfulness-based Intervention for Children and Young Adults With High Grade or High-Risk Cancer and Their CaregiversNo drug interventionssupportive_careNot Availablecompleted
NCT00575887
Efficacy of Protracted Temozolomide in Patients With Progressive High Grade Gliomatreatment2completed
NCT00080054
A Study of Motexafin Gadolinium and Temozolomide for the Treatment of Malignant Gliomastreatment1completed
NCT02209428
A Prospective Cohort to Study the Effect of Temozolomide on IDH Mutational Low Grade Gliomastreatment2unknown_status
NCT00624728
Assessment of 18FLT PET-CT for Volume Definition of High-grade Gliomas (GLIO-TEP)No drug interventionsdiagnostic1 / 2completed
NCT00783393
SCH 52365 Phase II Clinical Study: A Study on the Efficacy and Safety of Monotherapy With SCH 52365 in Patients With First Relapsed Anaplastic Astrocytoma (Study P03745)treatment2completed
NCT03911388
HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumorstreatment1active_not_recruiting
NCT04135807
Implantable Microdevice In Primary Brain TumorsNo drug interventionsdiagnostic0recruiting
NCT02747407
Qualitative, Qualitative, and Functional Studies Over the First Year in Measuring Immune System Response During the First Year of Therapy in Patients With Brain TumorsNot AvailableNot Availablecompleted
NCT00335075
Efficacy and Safety of Temodal vs Semustine in Subjects With Recurrent Glioblastoma or Anaplastic Astrocytoma (Study P03644)treatment3completed
NCT04430842
Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072SNo drug interventionstreatment1completed
NCT02010606
Phase I Study of a Dendritic Cell Vaccine for Patients With Either Newly Diagnosed or Recurrent Glioblastomatreatment1completed
NCT05236036
Mycophenolate Mofetil in Combination With Standard of Care for the Treatment of Glioblastomatreatment1recruiting
NCT01351519
A Study of Aminolevulinic Acid Used to Enhance Visualization and Surgical Removal of Brain Tumorstreatment2terminated
NCT00591058
Safety and Dose-Finding Study of TM-601 in Adults With Recurrent Malignant Gliomatreatment1unknown_status
NCT05393258
Temporally-modulated Pulsed Radiation Therapy (TMPRT) After Prior EBRT for Recurrent IDH-mutant GliomasNo drug interventionstreatmentNot Availablerecruiting
NCT02684058
Study of Efficacy and Safety of Dabrafenib in Combination With Trametinib in Pediatric Patients With BRAF V600 Mutation Positive LGG or Relapsed or Refractory HGG Tumorstreatment2completed
NCT01288235
Proton Radiotherapy for Pediatric Brain Tumors Requiring Partial Brain IrradiationNo drug interventionstreatment2active_not_recruiting
NCT01331135
Aflac ST0901 CHOANOME - Sirolimus in Solid Tumorstreatment1completed
NCT00795457
Effects of Vaccinations With HLA-A2-Restricted Glioma Antigen-Peptides in Combination With Poly-ICLC for Adults With High-Risk WHO Grade II Astrocytomas and Oligo-Astrocytomastreatment0completed
NCT00782626
Everolimus (RAD001) for Children With Chemotherapy-Refractory Progressive or Recurrent Low-Grade Gliomastreatment2completed
NCT02666066
Radiomics for Prediction of Survival in GBMNo drug interventionsNot AvailableNot Availablecompleted
NCT01044966
A Study of Intraventricular Liposomal Encapsulated Ara-C (DepoCyt) in Patients With Recurrent Glioblastomatreatment1 / 2terminated
NCT06161974
Study of Olutasidenib and Temozolomide in HGGtreatment2not_yet_recruiting
NCT06439420
CBT-I in Primary Brain Tumor Patients: Phase IIc Randomized Feasibility Pilot TrialNo drug interventionstreatment2recruiting
NCT03796273
Ketoconazole Before Surgery in Treating Patients With Recurrent Glioma or Breast Cancer Brain Metastasestreatment0terminated
NCT00723827
Temodal (Temozolomide) Post Marketing Surveillance Protocol (Study P05557AM2)Not AvailableNot Availablecompleted
NCT00165360
Prolonged Daily Temozolomide for Low-Grade Gliomatreatment2completed
NCT06241391
Ga-68 Prostate Specific Membrane Antigen PET/CT in GliomasNo drug interventionsdiagnosticNot Availablenot_yet_recruiting
NCT01089244
FET-PET for Diagnosis and Monitoring in Patients With Low Grade GliomaNo drug interventionsNot AvailableNot Availableunknown_status
NCT00921167
A Study to Evaluate the Efficacy of Bevacizumab Plus Irinotecan in Recurrent Gliomastreatment2completed
NCT03739372
Clinical Benefit of Using Molecular Profiling to Determine an Individualized Treatment Plan for Patients With High Grade GliomaNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT03722355
Hyperfractionated RT With BCNU Versus Conventional RT With BCNU for Supratentorial Malignant Gliomatreatment3completed
NCT01117155
A Pilot Study Evaluating 18F-L-Thymidine (FLT) PET Imaging in Children With GliomasNo drug interventionsNot AvailableNot Availablewithdrawn
NCT04047303
CNS Penetration, PK and PD of Preoperative CC-90010 in Progressive/Recurrent Diffuse Astrocytoma, Anaplastic Astrocytoma and Glioblastomatreatment1terminated
NCT00179803
Stem Cell Transplant for High Risk Central Nervous System (CNS) TumorsNo drug interventionstreatment2completed
NCT00389090
A Phase II Study of Temozolomide and O6-Benzylguanine (O6-BG) in Patients With Temozolomide-Resistant Anaplastic Gliomatreatment2terminated
NCT03649464
Investigation of Oral OKN-007 in Recurrent High-grade Glioma Participantstreatment1 / 2withdrawn
NCT03032484
TVB- 2640 in Combination With Bevacizumab in Patients With First Relapse of High Grade Astrocytomatreatment2completed
NCT04028479
The Registry of Oncology Outcomes Associated With Testing and TreatmentNo drug interventionsNot AvailableNot Availablerecruiting
NCT02764151
First in Patient Study for PF-06840003 in Malignant GliomasNo drug interventionstreatment1terminated
NCT01579253
Combined O-(2-[18F]Fluoroethyl)-L-tyrosine (FET) Positron Emission Tomography (PET) and Simultaneous Magnetic Resonance Imaging (MRI) Follow-up in Re-irradiated Recurrent Glioblastoma PatientsNo drug interventionsNot AvailableNot Availableunknown_status
NCT05686798
Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.No drug interventionstreatment1recruiting
NCT00705198
Temozolomide All-Case-Registered Surveillance (Designated Drug Use Investigation)(Study P05062)Not AvailableNot Availablecompleted
NCT01502605
Phase I Study of Orally Administered Aminolevulinic Acid for Resection of Malignant Astrocytomasdiagnostic1terminated
NCT00683761
A Study of 131I-TM601 in Adults With Recurrent Malignant GliomaNo drug interventionstreatment1 / 2unknown_status
NCT00874861
HLA-A2-Restricted Glioma Antigen-Peptides Vaccinations With Poly-ICLC for Recurrent WHO Grade II Gliomastreatment0completed
NCT00360828
Phase II Study of Irinotecan HCI for Recurrent Anaplastic Astrocytomas, Mixed Malignant Gliomas, and Oligodendrogliomasdiagnostic2terminated
NCT04327011
A Continuation Protocol for Patients Previously Enrolled in a Study of Toca 511treatment1terminated
NCT00392171
The Effects of Continuous 28-day (28/28) Temozolomide Chemotherapy in Subjects With Recurrent Malignant Glioma Who Have Failed the Conventional 5-day (5/28) Treatment (P04601)treatment2completed
NCT00994071
A Phase I Study of ABT-888, an Oral Inhibitor of Poly(ADP-ribose) Polymerase and Temozolomide in Children With Recurrent/Refractory CNS Tumorstreatment1completed
NCT02372409
Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Treatment of Pediatric Brain Tumorstreatment2terminated
NCT04970615
Educating Brain Tumor Patients Using Patient-specific Actual-size Three-dimensional Printed ModelsNo drug interventionsNot AvailableNot Availableunknown_status
NCT01849952
Evaluating the Expression Levels of MicroRNA-10b in Patients With GliomasNo drug interventionsNot AvailableNot Availablerecruiting
NCT01125800
A Phase I Dose Finding and Safety Study of Oral LDE225 in Children and a Phase II Portion to Assess Preliminary Efficacy in Recurrent or Refractory MBtreatment1 / 2completed
NCT05513859
Investigational Imaging Technique During Brain SurgeryNo drug interventionsdiagnosticNot Availablenot_yet_recruiting
NCT00154375
Study of Imatinib Mesylate in Combination With Hydroxyurea Versus Hydroxyurea Alone as an Oral Therapy in Patients With Temozolomide Resistant Progressive Glioblastomatreatment3completed
NCT06108206
Adaptive Radiotherapy and MRIs Based on Patients With Newly Diagnosed High-Grade GliomaNo drug interventionstreatmentNot Availablerecruiting
NCT05624736
Hierarchical Diagnosis for Adult Diffuse Glioma Based on Deep LearningNo drug interventionsNot AvailableNot Availablerecruiting
NCT03152318
A Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2treatment1recruiting
NCT02976441
Autologous Stem Cell Collection and Reinfusion in Newly Diagnosed High Grade Gliomastreatment0withdrawn
NCT00028158
Safety and Effectiveness Study of G207, a Tumor-Killing Virus, in Patients With Recurrent Brain CancerNo drug interventionstreatment1 / 2completed
NCT00009035
Natural History of Patients With Brain and Spinal Cord TumorsNo drug interventionsNot AvailableNot Availablecompleted
NCT01649830
Efficacy of Post-radiation Adjuvant Temozolomide Chemotherapy in Residue Low-grade Gliomatreatment3recruiting
NCT00001148
Detecting Malignant Brain Tumor Cells in the Bloodstream During Surgery to Remove the TumorNo drug interventionsNot AvailableNot Availablecompleted
NCT04648462
Proton Therapy Research Infrastructure- ProTRAIT- Neuro-oncologyNo drug interventionsNot AvailableNot Availablerecruiting
NCT03975829
Pediatric Long-Term Follow-up and Rollover Studytreatment4recruiting
NCT03900689
Social Determinants of Health in Glioblastoma PopulationNo drug interventionsNot AvailableNot Availablecompleted
NCT02529072
Nivolumab With DC Vaccines for Recurrent Brain Tumorstreatment1completed
NCT05532969
Correlation Between Psychological Stress and Progression of Diffuse Astrocytoma Towards Secondary GliomaNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT05683808
Venous Thromboembolism Prevention in Outpatients With Gliomasupportive_care2not_yet_recruiting
NCT00031538
Genetic Analysis of Brain TumorsNo drug interventionsNot AvailableNot Availableterminated
NCT01967758
Phase I Study of Safety and Immunogenicity of ADU-623treatment1completed
NCT01068782
Study of Multiple Doses and Regimens of XL184 (Cabozantinib) in Subjects With Grade IV Astrocytic Tumors in First or Second Relapsetreatment2completed