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T-cell immunoreceptor with Ig and ITIM domains
go.drugbank.com/bio_entities/BE0010742TargetHumansIn turn, inhibits PI3K and MAPK signaling cascades (PubMed:23154388). … In addition, associates with beta-arrestin-2/ARRB2 to recruit SHIP1/INPP5D that suppresses autoubiquitination of TRAF6 and subsequently inhibits NF-kappa-B signaling pathway (PubMed:24817116).
Polypeptides: T-cell immunoreceptor with Ig and ITIM domainsSynonyms: V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain-containing protein 3Belimumab
go.drugbank.com/drugs/DB08879ApprovedInvestigational[A251495, L42705] By binding to BLyS and blocking its interaction with B cell receptors, belimumab inhibits the survival of B cells. … [A251520] It is currently used to treat SLE and lupus nephritis.[L42630]
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsProducts: Benlysta Powder for Solution for Infusion 120mgValproate bismuth
go.drugbank.com/drugs/DB13910ApprovedValproate bismuth is available in Canada in the over-the-counter medication Neo-Laryngobis.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProducts: Neo-laryngobis, Neo Laryngobis EnfNilvadipine
go.drugbank.com/drugs/DB06712ApprovedNilvadipine is a calcium channel blocker (CCB) for the treatment of hypertension.
Categories: Calcium-Regulating Hormones and AgentsProducts: ESCOR FORTE 16MG RET KAPNilotinib
go.drugbank.com/drugs/DB04868ApprovedInvestigationalA Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to treatment with imatinib (Gleevec
Categories: Antineoplastic and Immunomodulating AgentsProducts: Tasigna Capsule 150mg, Tasigna 150mg CapsuleSodium iodide
go.drugbank.com/drugs/DB11119ApprovedInvestigationalSodium iodide is a source of iodine and can be administered as a supplement for total parenteral nutrition [L2065] but is more commonly used in veterinary medicine. … Radiolabelled compound, [DB09293], is used as a diagnostic tool to evaluate thyroid function and morphology.
Products: Sodium Iodide Inj 100mg/mlNedocromil
go.drugbank.com/drugs/DB00716ApprovedA pyranoquinolone derivative that inhibits activation of inflammatory cells which are associated with asthma, including eosinophils, neutrophils, macrophages, mast cells, monocytes, and platelets.
Categories: Decongestants and AntiallergicsProducts: Tilade Inhaler 2mg/aemRomosozumab
go.drugbank.com/drugs/DB11866ApprovedInvestigationalIn a comparison study of post menopausal women with osteoporosis and a past fracture, romosozumab for 12 months followed by alendronic acid for 12 months was superior to alendronic acid alone for 24 months … Romosozumab also demonstrates a faster and larger increase in bone density than teriparatide[A177050]. Romosozumab is marketed in the United States by Amgen under the brand name Evinity[L5921].
Categories: Amino Acids, Peptides, and Proteins, Drugs Affecting Bone Structure and MineralizationProducts: EVENITY SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 105MG/1.17ML, EVENITY® 90MG/MLDexketoprofen
go.drugbank.com/drugs/DB09214ApprovedInvestigationalWithdrawnDexketoprofen is a non-steroidal anti-inflammatory drug. It is available in the various countries in Europe, Asia and Latin America. … It has analgesic, antipyretic and anti-inflammatory properties [L1298].
Mixtures: TIYOKAS 25MG/4MG SAŞE, 20 SAŞE, TIYOKAS 25MG/8MG SAŞE, 14 SAŞECategories: Antiinflammatory and Antirheumatic Products, Non-Steroids, Ketoprofen and isomerMexiletine
go.drugbank.com/drugs/DB00379ApprovedInvestigationalAntiarrhythmic agent pharmacologically similar to lidocaine. It may have some anticonvulsant properties.
Products: Mexitil Cap 100mg