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Gimeracil
go.drugbank.com/drugs/DB09257ApprovedInvestigationalBy mimicking a class of compounds called "pyrimidines" that are essential components of RNA and DNA, 5-FU is able to insert itself into strands of DNA and RNA, thereby halting the replication process necessary … This allows higher concentrations of 5-FU to be achieved with a lower dose of tegafur, thereby also reducing toxic side effects.
Mixtures: TS-ONE OD Tablet 20, TS-ONE OD Tablet 25Sodium bisulfite
go.drugbank.com/drugs/DB14015ApprovedWithdrawnSodium bisulfite has been used externally for parasitic skin diseases and as a gastrointestinal antiseptic.
Mixtures: LIBAVIT-K 20 MG AMPUL, 5 ADETCategories: Compounds used in a research, industrial, or household settingSimeprevir
go.drugbank.com/drugs/DB06290ApprovedWithdrawnor longer to 12 or 24 weeks [A19630] depending on prior response status and presence of HIV-1 co-infection. … or second-line threapies for treatment-naïve patients as adjunct to sofosbuvir treatment for genotype 1 or PEG-Interferon/ribavirin combination therapy for genotype 1 or 4.
Categories: combinations of sulfonamides, Antivirals for treatment of HCV infectionsProducts: OLYSIO 150 MG KAPSUL ,KAPSUL, 28 ADETRibavirin
go.drugbank.com/drugs/DB00811ApprovedInvestigationalCombination therapy of ribavirin and [DB00008] results in the SVR of 44% in patients with genotype 1 infection and 70% in patients with genotype 2-6. … Newer drugs developed as Hepatitis C viral infection treatments can be used to reduce or eliminate the use of ribavirin, which are associated with serious adverse effects.
Categories: Antivirals for treatment of HCV infectionsProducts: MODERIBA® 200 MG, COPEGUS TABLET 200 mgLevoleucovorin
go.drugbank.com/drugs/DB11596ApprovedInvestigationalThey are indicated for use as rescue therapy following use of high-dose methotrexate in the treatment of osteosarcoma or for diminishing the toxicity associated with inadvertent overdosage of folic acid … This results in a deficiency of coenzymes and a resultant buildup of toxic substances that are responsible for numerous adverse side effects of methotrexate therapy.
Categories: Compounds used in a research, industrial, or household settingNitrogen
go.drugbank.com/drugs/DB09152ApprovedInvestigationalVet approvedLiquid nitrogen helps in removal of skin lesions through necrosis, which results from the freezing and thawing of cells. Cryotherapy usually done in doctors' office. … Liquid nitrogen is used principally in cryotherapy for removal of diseased skin.
Mixtures: Co-NE-O2-N2 Mixture, Co-HE-O2-N2 MixtureATX-101
go.drugbank.com/drugs/DB05780InvestigationalATX-101 demonstrates a relative selectivity for fat over other tissues. … of the body.
Clenbuterol
go.drugbank.com/drugs/DB01407ApprovedInvestigationalVet approvedA substituted phenylaminoethanol that has beta-2 adrenomimetic properties at very low doses. It is used as a bronchodilator in asthma.
Mixtures: SERBOL-G, VAKSAN COMPOSITUM JARABE ADULTOS 15 MG/0.01 MG/ 5MLFlupentixol
go.drugbank.com/drugs/DB00875ApprovedInvestigationalWithdrawn[L31808] It has been marketed to manage symptoms of depression in patients who may or may not exhibit signs of anxiety. … It is used for the management of chronic schizophrenia in patients whose main manifestations do not include excitement, agitation or hyperactivity.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProducts: FLUANXOL 1 MG, FLUPENTIXOL-NEURAX 200 MGTechnetium Tc-99m mebrofenin
go.drugbank.com/drugs/DB09137ApprovedWithdrawnFollowing intravenous injection, single photon emission computer tomography (SPECT) imaging of the liver or gallbladder is performed using a gamma camera to detect the gamma rays emitted by the technetium … Currently available within a sterile kit, Tc-99m Mebrofenin is indicated for imaging of the liver and gallbladder.
Categories: Diagnostic Uses of Chemicals, Compounds used in a research, industrial, or household setting