Nitrogen

DB09152ApprovedInvestigationalVet approvedSmall molecule

Nitrogen is a cryogenic agent used to treat various benign and malignant skin lesions. Nitrogen is a chemical element with symbol N and atomic number 7.

Mechanism: In cryotherapy, mechanism of action could be classified into three stages: 1. heat transfer, 2. cell injury and 3. inflammation. Boiling point of liquid nitrogen is -196°C, which is the responsible for creating the initial stage which is heat transfer. The second stage is cell injury which is induced during thawing conditions of the cells. The last step in the cryotherapy is the inflammation stage which is characterized by edema and erythema. Inflammation occurs as a result of cellular death and it helps in local cell destruction.
Curator reviewed
Primary indication: Liquid nitrogen is used mainly as a cryogenic agent for the treatment of various benign and malignant skin lesions.Curator reviewed · 5 structured indications
Formula / weight: N₂ · 28.0134 g/mol (avg)
First approval: Canada, 2011 · United States, 1938
Code names: E-941 · INS-941 · INS NO.941
Brand names: Nitrogen NF

Resolves to

Compound

UNIIN762921K75CAS7727-37-9ChEMBLCHEMBL142438ChEBI17997PubChem947KEGGD00083

Clinical / RWD

RxNorm7456ATCV03AN04

Structure

InChIKeyIJGRMHOSHXDMSA-UHFFFAOYSA-NSMILESN#N

What you can answer from here — as of May 03, 2025

51Clinical trialsPhase, status and sponsor resolved per trial

5Structured indicationsCondition, population, route and combination as fields, not prose

300Marketed productsAcross 4 countries and 208 labellers

1ATC codeIncluding every combination product, plus 5 drug categories

6+ReferencesStructured and connected to the statements they support

Which other approved drugs treat the same conditions as Nitrogen, and which companies have late-stage candidates in those indications?

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