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Yohimbine
go.drugbank.com/drugs/DB01392ApprovedInvestigationalVet approvedWithdrawnA plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.
Lepirudin
go.drugbank.com/drugs/DB00001ApprovedWithdrawn[L41539] Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence of sulfate on the tyrosine residue at position 63 and the substitution of leucine for isoleucine
Selenious acid
go.drugbank.com/drugs/DB11127ApprovedSelenious acid is the acid form of sodium selenite, a form of selenium [L1910]. Selenium is an essential trace element and antioxidant. It is a cofactor metabolic enzyme regulation. … Interestingly, selenium is being studied as a potential therapy in the prevention or management of atherosclerosis [L1921].
Mixtures: Addaven Concentrate for Solution for Infusion, ADDAVEN CONCENTRATE FOR SOLUTION FOR INFUSIONDiazoxide
go.drugbank.com/drugs/DB01119ApprovedInvestigationalFDA-approved therapy for this condition. … [A190372] When administered intravenously, diazoxide can be used to treat hypertensive emergencies;[L44622] however, this specific form of diazoxide is no longer available in the US.
Maftivimab
go.drugbank.com/drugs/DB15899ApprovedInvestigational[A221825, A221830] A recent large-scale study elucidated that both neutralizing and Fc-mediated functions of antibodies were important for therapeutic benefit in animal models of EBOV infection. … Ebola virus (EBOV) remains an important human pathogen within the _Ebolavirus_ genus, having been responsible for at least 17 known outbreaks with an average case fatality rate of 43.92%.
Categories: Treatments for Ebola Virus DiseaseTetrodotoxin
go.drugbank.com/drugs/DB05232InvestigationalAn aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order tetraodontiformes, which are eaten. … Tetrodotoxin is being investigated by Wex Pharmaceuticals for the treatment of chronic and breakthrough pain in advanced cancer patients as well as for the treatment of opioid dependence.
Categories: Compounds used in a research, industrial, or household settingFlibanserin
go.drugbank.com/drugs/DB04908ApprovedInvestigationalFlibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. … In February of 2018 Flibanserin was approved by Health Canada under the brand name Addyi for a similar indication as approved by the FDA.
Ceftolozane
go.drugbank.com/drugs/DB09050ApprovedInvestigational[L6685] It was approved by the FDA in 2014 for use in combination with [Tazobactam] for the treatment of serious infections, such as intra-abdominal infections and complicated urinary tract infections. … [A179422] Most recently, in June 2019, ceftolozane-tazobactam was approved for the treatment of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia.
Mixtures: ZERBAXA POWDER FOR SOLUTION FOR INJECTION 1G/0.5G, Zerbaxa 1.5g powder for solution for injectionBrensocatib
go.drugbank.com/drugs/DB15638Approved[A274348] Brensocatib was approved by the US FDA on August 12, 2025, for use in adults and pediatric patients with NCFB.[L53808,L53813]
Datopotamab deruxtecan
go.drugbank.com/drugs/DB16410ApprovedInvestigational[L52215] Datopotamab deruxtecan-dlnk (Datroway) was approved by the US FDA in January 2025 for the treatment of hormone receptor positive, HER2 negative unresectable or metastatic breast cancer. … [L52130,L52220] In June 2025, it was granted an accelerated approval by the FDA for the treatment non-small cell lung cancers with EGFR mutations.[L53623]