Yohimbine is an alpha-2-adrenergic blocker and sympatholytic found in supplements used to. A plant alkaloid with alpha-2-adrenergic blocking activity.
- Mechanism
- Curator reviewed
Yohimbine is a pre-synaptic alpha 2-adrenergic blocking agent. The exact mechanism for its use in impotence has not been fully elucidated. However, yohimbine may exert its beneficial effect on erectile ability through blockade of central alpha 2-adrenergic receptors producing an increase in sympathetic drive secondary to an increase in norepinephrine release and in firing rate of cells in the brain noradrenergic nuclei. Yohimbine-mediated norepinephrine release at the level of the corporeal tissues may also be involved. In addition, beneficial effects may involve other neurotransmitters such as dopamine and serotonin and cholinergic receptors.
- Primary indication
- Indicated as a sympatholytic and mydriatic.Curator reviewed · 1 structured indication
- Formula / weight
- C21H26N2O3 · 354.4427 g/mol (avg)
- First approval
- Canada, 2009
- Also known as
- Yohimbic acid methyl ester
Resolves to
BLGXFZZNTVWLAY-SCYLSFHTSA-NSMILES[H][C@@]12CC[C@H](O)[C@H](C(=O)OC)[C@@]1([H])C[C@]1([H])N(CCC3=C1NC1=CC=CC=C31)C2What you can answer from here — as of September 23, 2026
Which drugs share a target with Yohimbine, and which of those have an active Phase 3 trial?
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