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Displaying results 1411 - 1420 of 5384 in total
  1. Drug

    Fostemsavir

    go.drugbank.com/drugs/DB11796
    ApprovedInvestigational

    [A215057] Fostemavir is the first attachment inhibitor to receive FDA approval, granted in July 2020 for use in combination with other antiretrovirals in highly treatment-experienced patients with multidrug-resistant

    Categories: Antivirals for Systemic Use, Antiinfectives for Systemic Use
  2. Drug

    Busulfan

    go.drugbank.com/drugs/DB01008
    ApprovedInvestigational

    It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about.

  3. Drug

    Pentastarch

    go.drugbank.com/drugs/DB09111
    ApprovedWithdrawn

    It is sold under the name Pentaspan by Bristol-Myers Squibb and is used for fluid resuscitation. … Pentastarch is characterized by presenting five hydroxyethyl groups, which signifies an approximate 50% hydroxyethylation.

  4. Drug

    Etoricoxib

    go.drugbank.com/drugs/DB01628
    ApprovedInvestigationalWithdrawn

    It is approved in more than 60 countries worldwide but not in the US.

  5. Drug

    Profenamine

    go.drugbank.com/drugs/DB00392
    Approved

    [L46812] In the US, the marketing of profenamine has been discontinued.[L46817]

  6. Drug

    Olodaterol

    go.drugbank.com/drugs/DB09080
    ApprovedInvestigational

    Elevation of these two molecules induces bronchodilation by relaxation of airway smooth muscles. … Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs.

  7. Drug

    Silver

    go.drugbank.com/drugs/DB12965
    ApprovedInvestigational

    However, some drawbacks of dental use of silver compounds include tooth discolouration and pulp irritation [A33141].

  8. Drug

    Varicella zoster vaccine (live/attenuated)

    go.drugbank.com/drugs/DB10318
    ApprovedInvestigational

    This is a significant improvement over its predecessor, Zostavax, which reduces the risk of shingles by only 51% and the risk of post-herpetic neuralgia by 67% [A31349]. … First approved in May 2006 by the Food and Drug Administration, Zostavax was the first vaccine available for the prevention of shingles.

    Categories: Antiinfectives for Systemic Use
  9. Drug

    Cannabidivarin

    go.drugbank.com/drugs/DB14050
    Investigational

    In October 2017 CBDV was given orphan designation by the European Medicines Agency for use in Rett Syndrome [L2952] and again in February 2018 for treatment of Fragile X Syndrome [L2951]. … They will continue to study its use in epilepsy, however, and are expanding their investigations to include its potential use in Autism Spectrum Disorder, Rett syndrome and Fragile X among others [L2949

  10. Drug

    Protriptyline

    go.drugbank.com/drugs/DB00344
    Approved

    In addition, TCAs down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. … In non-depressed individuals, protriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, protriptyline exerts a positive effect on mood.