Identification

Summary

Pentastarch is a plasma volume expander used as an adjunct in the management of shock due to hemorrhage, surgery, sepsis, burns or other trauma.

Generic Name
Pentastarch
DrugBank Accession Number
DB09111
Background

Pentastarch is an artificial colloid (hydroxyethyl starch derivative). Pentastarch is characterized by presenting five hydroxyethyl groups, which signifies an approximate 50% hydroxyethylation. It is sold under the name Pentaspan by Bristol-Myers Squibb and is used for fluid resuscitation. When administered, pentastarch remains mainly in the circulatory system and hence, it is considered a plasma expander.

Type
Small Molecule
Groups
Approved, Investigational
Synonyms
  • Pentastarch
External IDs
  • ASL 607

Pharmacology

Indication

The primary intended use of pentastarch is as a substitute for older colloids such as albumin or hetastarch for use in plasma volume expansion.

Pharmacology
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Associated Therapies
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Pentastarch is hydrolyzed by plasma amylase. This is more rapid and complete compared to hetastarch.

Route of elimination

As a result of its lower molecular weight and lesser degree of substitution, pentastarch is eliminated from the circulation at a faster rate than hetastarch. Ordinarily, only 10% of an intravenous dose remains after 24 hours, and levels are undetectable after 4 to 7 days. Up to 70% of a dose is excreted in the urine within 24 hours.

Half-life

~2.5 hours.

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbacavirAbacavir may decrease the excretion rate of Pentastarch which could result in a higher serum level.
AceclofenacAceclofenac may decrease the excretion rate of Pentastarch which could result in a higher serum level.
AcemetacinAcemetacin may decrease the excretion rate of Pentastarch which could result in a higher serum level.
AcetaminophenAcetaminophen may decrease the excretion rate of Pentastarch which could result in a higher serum level.
AcetazolamideAcetazolamide may increase the excretion rate of Pentastarch which could result in a lower serum level and potentially a reduction in efficacy.
Acetylsalicylic acidAcetylsalicylic acid may decrease the excretion rate of Pentastarch which could result in a higher serum level.
AclidiniumAclidinium may decrease the excretion rate of Pentastarch which could result in a higher serum level.
AcrivastinePentastarch may decrease the excretion rate of Acrivastine which could result in a higher serum level.
AcyclovirAcyclovir may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Adefovir dipivoxilAdefovir dipivoxil may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Interactions
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Food Interactions
Not Available

Products

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International/Other Brands
StarQuin (Biomed)

Categories

Drug Categories
Classification
Not classified
Affected organisms
  • Humans and other mammals

Chemical Identifiers

UNII
MOQ3RNM0SV
CAS number
9005-27-0
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

References

General References
  1. Younes RN, Yin KC, Amino CJ, Itinoshe M, Rocha e Silva M, Birolini D: Use of pentastarch solution in the treatment of patients with hemorrhagic hypovolemia: randomized phase II study in the emergency room. World J Surg. 1998 Jan;22(1):2-5. [Article]
PubChem Substance
347910411
RxNav
816249
Drugs.com
Drugs.com Drug Page
Wikipedia
Pentastarch
FDA label
Download (28.9 KB)
MSDS
Download (220 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
Not AvailableCompletedNot AvailableAvascular Necrosis of Hip / Total Hip Replacement Arthroplasty1
Not AvailableCompletedTreatmentElective Cesarean Section1
Not AvailableUnknown StatusTreatmentCardiopulmonarybypass / Surgery, Cardiac1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
InjectionIntravenous
SolutionIntravenous10 g / 100 mL
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at September 17, 2015 21:45 / Updated at February 21, 2021 18:52