Protriptyline

DB00344ApprovedSmall moleculeAntidepressive Agents Indicated for DepressionAntidepressive Agents, Tricyclic

Protriptyline is a tricyclic antidepressant that is indicated in the treatment of depression only under close clinical supervision. TCAs are structurally similar to phenothiazines.

Chemical structure of Protriptyline
Mechanism
Curator reviewed
Primary indication
For the treatment of depression.Curator reviewed · 1 structured indication
Formula / weight
C19H21N · 263.3767 g/mol (avg)
First approval
Canada, 1966 · United States, 2000
Also known as
Amimetilina
Code names
MK-240

Resolves to

Compound
UNII4NDU154T12CAS438-60-8ChEMBLCHEMBL668ChEBI8597PubChem4976KEGGD08447
Clinical / RWD
RxNorm8886ATCN06AA11PharmGKBPA451168
Structure
InChIKeyBWPIARFWQZKAIA-UHFFFAOYSA-NSMILESCNCCCC1C2=CC=CC=C2C=CC2=CC=CC=C12
Targets
P23975SLC6A2P31645SLC6A4
Transporters
P08183ABCB1

What you can answer from here — as of September 23, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
1TransporterSubstrate / inhibitor direction, not just membership
Listed above
1,580Drug interactionsStructured to mechanism, not free text
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1Clinical trialPhase, status and sponsor resolved per trial
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1Structured indicationCondition, population, route and combination as fields, not prose
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3ContraindicationsEach with its own population and attribute set
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16Marketed productsAcross 2 countries and 9 labellers
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1ATC codeIncluding every combination product, plus 27 drug categories
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18+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Protriptyline, and which of those have an active Phase 3 trial?

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