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Ritlecitinib
go.drugbank.com/drugs/DB14924ApprovedInvestigationalIt has been suggested that the dual activity of ritlecitinib toward JAK3 and the TEC kinase family block cytokine signaling as well as the cytolytic activity of T cells, both implicated in the pathogenesis ā¦ [A260122,A260127] Ritlecitinib binds covalently to Cys-909 of JAK3, a site where other JAK isoforms have a serine residue.
Synonyms: 2-propen-1-one, 1-((2S,5R)-2-methyl-5-(7H-pyrrolo(2,3-D)pyrimidin-4-ylamino)-1-piperidinyl)-Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsFezolinetant
go.drugbank.com/drugs/DB15669ApprovedInvestigational[A259591,A259542] Lower estrogen levels during menopause will decrease the estrogen-mediated feedback loop and increase neurokinin B signalling, increasing the activity of KNDy neurons and therefore the ā¦ [A259606] Estrogen is a potent neuromodulator, particularly in the hypothalamus, and has been shown to be involved as a negative regulator in generating Gonadotropin-releasing hormone (GnRH) pulse through
Categories: Neurokinin 3 Receptor Antagonist, Cytochrome P-450 SubstratesRipasudil
go.drugbank.com/drugs/DB13165InvestigationalRipasudil is a well tolerated medication that is used when other drugs have been proven to be non-effective or cannot be administered. ā¦ Ripasudil, as hydrochloride hydrate (K-115), is a specifc Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor used for the treatment of glaucoma and ocular hypertension.
Categories: Heterocyclic Compounds, 2-RingProducts: GLANATEC OPHTHALMIC SOLUTION 0.4% W/VMK-3207
go.drugbank.com/drugs/DB12424InvestigationalMk3207 has been used in trials studying the treatment of Migraine and Migraine Disorders.
Categories: Receptors, Calcitonin Gene-Related Peptide, antagonists & inhibitorsEbola Zaire vaccine (live, attenuated)
go.drugbank.com/drugs/DB15595ApprovedInvestigational[A188997] Confirmed outbreaks of Ebola virus disease have been documented since the 1970s, mostly in Sub-Saharan Africa, where Ebola first appeared in 1976 near the Ebola River in Zaire (presently referred ā¦ [L10866] In 2014, Merck Inc. signed a licensing agreement with NewLink for further development and marketing.
Synonyms: Ebola Zaire Vaccine (rVSVāG-ZEBOV-GP, live), EBOLA ZAĆRE VACCINE (rVSV [DELTA] G-ZEBOV-GP, LIVE)Stem bromelain
go.drugbank.com/drugs/DB12249ApprovedThe primary therapeutic use for which stem bromelain is currently and formally indicated is as a burn wound eschar debridement agent that has been approved by the EMA since 2012 and marketed under the ā¦ Bromelain itself belongs to a category of protein-digesting enzymes that are obtained commercially from the fruit or stem of pineapples [A27198].
Octinoxate
go.drugbank.com/drugs/DB09496ApprovedInvestigationalIt was originally developed in 1950's as an organic UV-B filter that absorbs UV-B rays from sun. ā¦ Octinoxate is a cinnamate ester and common ingredient in sunscreen and other skin care products to minimize DNA photodamage.
Synonyms: ethylhexyl p-methoxycinnamateMixtures: Green Stick, Lip Balm Green Tea FlavoredBromfenac
go.drugbank.com/drugs/DB00963ApprovedWithdrawnBromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation.
Categories: Selective Cyclooxygenase 2 Inhibitors (NSAIDs)Synonyms: [2-Amino-3-(4-bromo-benzoyl)-phenyl]-acetic acid, 2-amino-3-(4-bromobenzoyl)benzeneacetic acidAuranofin
go.drugbank.com/drugs/DB00995ApprovedInvestigationalIt has subsequently been listed by the World Health Organization as a member of the antirheumatic agent category. Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA. ā¦ Heme oxygenase 1 is an inducible heme-degrading enzyme with anti-inflammatory properties.
Synonyms: 2,3,4,6-Tetra-O-acetyl-1-thio-beta-D-glucopyranosato-S (triethylphosphine)gold, (1-Thio-beta-D-glucopyranosato)(triethylphosphine)gold 2,3,4,6-tetraacetateVenlafaxine
go.drugbank.com/drugs/DB00285ApprovedInvestigational[A252065] Venlafaxine has been used as a first-line treatment for MDD, GAD, social anxiety disorder, and panic disorder in Canada for many years. ā¦ Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI).
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: VENOXORĀ®75 MG, M-venlafaxine XR