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Displaying results 141 - 150 of 134474 in total
  1. Pathway

    Warfarin Action Pathway (New)

    smpdb.ca/view/SMP0124982
    Drug action

    By doing this the carboxylation of vitamin-k dependent factors such as II, VII, IX and X are prevented. … This ultimately leads to interference with coagulation, because of this patient should not give blood during the time they are using Warfarin.

    Drugs: Warfarin · Phylloquinone · Calcium
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  2. Pathway

    Phenprocoumon Action Pathway

    smpdb.ca/view/SMP0000271
    Drug action

    As vitamin K is a cofactor for the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulation factors (II, VII, IX, and X), this ultimately results in reduced cleavage of fibrinogen … into fibrin and decreased coagulability of the blood.

    Drugs: Phenprocoumon · Phylloquinone · Calcium
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  3. Pathway

    Acenocoumarol Action Pathway

    smpdb.ca/view/SMP0000269
    Drug action

    Vitamin K-dependent coagulation factors (II, VII, IX, and X) requires its cofactor, vitamin K to facilitate the activation and gamma-carboxylation. … Inhibition of vitamin K reductase results in reduced concentration of vitamin KH2, which will ultimately lead to decreased coagulability of the blood and reduced cleavage of fibrinogen into fibrin.

    Drugs: Phylloquinone · Calcium · Acenocoumarol
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  4. Pathway

    Dicumarol Action Pathway

    smpdb.ca/view/SMP0000270
    Drug action

    Vitamin K-dependent coagulation factors (II, VII, IX, and X) requires its cofactor, vitamin K to facilitate the activation and gamma-carboxylation. … Inhibition of vitamin K reductase results in reduced concentration of vitamin KH2, which will ultimately lead to decreased coagulability of the blood and reduced cleavage of fibrinogen into fibrin.

    Drugs: Dicoumarol · Phylloquinone · Calcium
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  5. Pathway

    Ximelagatran Action Pathway

    smpdb.ca/view/SMP0000279
    Drug action

    This enzyme also catalyzes precursors of prothrombin and coagulation factors VII, IX and X to prothrombin, and coagulation factors VII, IX and X. … Coming back to the factors transported from the liver, coagulation factor X is catalyzed into a group of enzymes called the tenase complex: coagulation factor IX and coagulation factor VIIIa (platelet

    Drugs: Phylloquinone · Calcium · Ximelagatran
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  6. Pathway

    Tranexamic Acid Action Pathway

    smpdb.ca/view/SMP0000287
    Drug action

    This enzyme also catalyzes precursors of prothrombin and coagulation factors VII, IX and X to prothrombin, and coagulation factors VII, IX and X. … Coming back to the factors transported from the liver, coagulation factor X is catalyzed into a group of enzymes called the tenase complex: coagulation factor IX and coagulation factor VIIIa (platelet

    Drugs: Tranexamic acid · Phylloquinone · Calcium
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  7. Pathway

    Phenindione Action Pathway

    smpdb.ca/view/SMP0000655
    Drug action

    Phenindione is a medication that is used as an anticoagulant. Anticoagulants are drugs that prevent the blood from coagulating and creating blood clots. … It is used to treat a variety of conditions, including cerebral and pulmonary embolisms, as well as cardiomyopathy.

    Drugs: Phenindione · Phylloquinone · Calcium
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  8. Pathway

    Fondaparinux.

    smpdb.ca/view/SMP0000273
    Drug action

    This enzyme also catalyzes precursors of prothrombin and coagulation factors VII, IX and X to prothrombin and coagulation factors VII, IX and X. … Coming back to the factors transported from the liver, coagulation factor X is catalyzed into a group of enzymes called the tenase complex: coagulation factor IX and coagulation factor VIIIa (platelet

    Drugs: Fondaparinux · Phylloquinone · Calcium
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  9. Pathway

    Heparin.

    smpdb.ca/view/SMP0000274
    Drug action

    Activated antithrombin III will inactive prothrombin and factor Xa (also other proteases). … The main mechanism of heparin is acting on increasing the rate of antithrombin-related neutralization of coagulation factors for certain activated type.

    Drugs: Phylloquinone · Heparin · Calcium
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  10. Pathway

    Enoxaparin.

    smpdb.ca/view/SMP0000272
    Drug action

    The drug increases the inactivation of coagulation factors IXa, Xa and XIIa. This increases the antithrombin effects. … They also are not inactivated by platelet factor 4 and does not bind endothelial cells or macrophages thus are not degraded as fast.

    Drugs: Ardeparin · Phylloquinone · Calcium
    Enzymes: Coagulation factor IX, Coagulation factor VIII