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Displaying results 141 - 150 of 2691 in total
  1. Drug

    Stachyose

    go.drugbank.com/drugs/DB19276
    Experimental

    Synonyms: Gal(.alpha.1->6)gal(.alpha.1->6)glc(.alpha.1->2.beta.)fru
  2. Drug

    Nelipepimut-S

    go.drugbank.com/drugs/DB06226
    Investigational

    Synonyms: Human receptor tyrosine-protein kinase erbB-2 (proto-oncogene Neu, tyrosine kinase-type cell surface receptor HER2, CD340)-(347-355)-peptideCategories: Receptor Protein-Tyrosine Kinases, Receptor, Epidermal Growth Factor
  3. Target

    Tyrosine-protein kinase FRK

    go.drugbank.com/bio_entities/BE0004742
    TargetHumans

    Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation.

    Polypeptides: Tyrosine-protein kinase FRK
  4. Drug

    Talquetamab

    go.drugbank.com/drugs/DB16678
    ApprovedInvestigational

    [L48822] On August 9, 2023, talquetamab was granted FDA accelerated approval.[L47770] … Talquetamab is a IgG4-PAA bispecific G protein-coupled receptor class C group 5 member D (GPRC5D)-directed CD3 T-cell engager.

    Synonyms: IMMUNOGLOBULIN G4-KAPPA/G4-LAMBDA, ANTI-(HOMO SAPIENS GPRC5D (G PROTEIN-COUPLED RECEPTOR CLASS C GROUP 5 MEMBER D)), AND ANTI-(HOMO SAPIENS CD3E (CD3 EPSILON, LEU-4)), HUMANIZED AND CHIMERIC MONOCLONAL, IMMUNOGLOBULIN G4-KAPPA/G4-LAMBDA, ANTI-(HOMO SAPIENS GPRC5D (G PROTEIN-COUPLED RECEPTOR CLASS C GROUP 5 MEMBER D)), AND ANTI-(HOMO SAPIENS CD3E (CD3 EPSILON, LEU-4)), HUMANIZED AND CHIMERIC MONOCLONAL
  5. Drug

    Famotidine

    go.drugbank.com/drugs/DB00927
    ApprovedInvestigational

    [L11166] Compared to other H<sub>2</sub> receptor antagonists, famotidine displays high selectivity towards this receptor; in a study consisting of healthy volunteers and patients with acid hypersecretory … Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion.

    Products: FAMOTIDIN RATIOPH 20MG FTA, FAMOTIDIN RATIOPH 40MG FTA
  6. Drug

    PBCAR20A

    go.drugbank.com/drugs/DB17189
    Investigational

    Synonyms: Allogeneic gene edited CD20-directed CAR (Chimeric Antigen Receptor) T cells
  7. Drug

    Trastuzumab duocarmazine

    go.drugbank.com/drugs/DB16342
    Investigational

    Trastuzumab duocarmazine is under investigation in clinical trial NCT03262935 (SYD985 vs. Physician's Choice in Participants With Her2-positive Locally Advanced or Metastatic Breast Cancer).

    Synonyms: Immunoglobulin g1-kappa, anti-(homo sapiens erbb2 (epidermal growth factor receptor 2, receptor tyrosineprotein kinase erbb-2, egfr2, her2, her-2, p185cerbb2, neu, cd340)), humanized monoclonal antibodyCategories: HER2 (Human Epidermal Growth Factor Receptor 2) inhibitors
  8. Drug

    TOL-101

    go.drugbank.com/drugs/DB16980
    Investigational

    Synonyms: Murine IgM monoclonal antibody specific for the human alpha, beta T cell receptor
  9. Drug

    Becotatug

    go.drugbank.com/drugs/DB19069
    Investigational

    JMT101 in Combination With Osimertinib, Versus Cisplatin-pemetrexed in Participants With Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) Characterized by Epithermal Growth Factor Receptor

    Synonyms: Jmt101 (fully human monoclonal igg1 antibody targeting epidermal growth factor receptor (egfr)), Immunoglobulin G1, anti-(human epidermal growth factor receptor) (human-Mus musculus monoclonal JMT101 γ1-chain), disulfide with human-Mus musculus monoclonal JMT101 κ-chain, dimer
  10. Pathway

    Sphingolipid Signaling (Receptor)

    smpdb.ca/view/SMP0524344
    Signaling

    Through these receptor‑specific G protein couplings—spanning cAMP suppression, Ca²⁺ mobilization, PKC activation, Rho GTPase–driven cytoskeletal remodeling, and PI3K/Akt and MAPK pathways—S1P orchestrates

    Drugs: Nitric oxide · Calcium · Magnesium cation
    Enzymes: Sphingosine 1-phosphate receptor 2, Sphingosine 1-phosphate receptor 4