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Ranolazine
go.drugbank.com/drugs/DB00243ApprovedInvestigational[L3580] With a mechanism of action different from drugs used to treat the same condition, ranolazine is a promising anti-anginal therapy. It was originally approved by the FDA in 2006.[L5440] … Chronic angina is a common cardiovascular condition affecting millions worldwide and causes significant disability while interfering with daily activities.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsProducts: Rande 750 mg Retardtabletten, Ranva 750 mg RetardtablettenTrabectedin
go.drugbank.com/drugs/DB05109ApprovedInvestigationalFood and Drug Administration (FDA) have approved trabectedin as an orphan drug in soft tissue sarcomas and ovarian cancer. … Trabectedin, also referred as ET-743 during its development, is a marine-derived antitumor agent discovered in the Carribean tunicate _Ecteinascidia turbinata_ and now produced synthetically.
Categories: Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic IndexProducts: YONDELIS 1 MG IV KONSANTRE INFUZYONLUK COZELTI ICIN TOZ, Trabectedin TEVA 0,25 mg Pulver für ein Konzentrat zur Herstellung einer InfusionslösungCaspofungin
go.drugbank.com/drugs/DB00520ApprovedInvestigationalCaspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug class called the echinocandins, as coined by Merck & Co., Inc. … It shows activity against infections with Aspergillus and Candida, and works by inhibiting β(1,3)-D-Glucan of the fungal cell wall.
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsProducts: CASPOFUNGINA 50 MG/VIAL POLVO PARA RECONSTITUIR A SOLUCION INYECTABLE, CASPOVITAE® 50 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION INYECTABLEAldesleukin
go.drugbank.com/drugs/DB00041ApprovedInvestigationalAldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. … Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2.
Categories: Cytochrome P-450 CYP2E1 Inhibitors, Cytochrome P-450 CYP3A InhibitorsProducts: PROLEUKIN 18X106 IU/ML STERİL IV LİYOFİLİZE TOZ İÇEREN FLAKON, 1 ADET, Proleukin 18 x 10 6 IE - Pulver zur Herstellung einer Injektions- oder InfusionslösungAnti-SARS-CoV-2 REGN-COV2
go.drugbank.com/drugs/DB15691InvestigationalAnti-SARS-COV-2 REGN-COV2 is a combination of novel antibodies designed by Regeneron for both the prevention and treatment of SARS-COV-2, the virus that causes COVID-19. … These antibodies have been formulated to bind to multiple locations on the SARS-COV-2 spike protein, preventing viral escape.
Synonyms: Anti-SARS-CoV-2 REGN-COV2Sipavibart
go.drugbank.com/drugs/DB21908ApprovedInvestigational[A274098] It works by binding to the SARS-CoV-2 spike protein receptor binding domain (RBD), neutralize the virus and preventing its entry into the host cell. … Sipavibart is a recombinant human IgG1 monoclonal antibody that is long-acting.
Synonyms: Immunoglobulin G1-lambda, anti-[Homo sapiens severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein, receptor binding domain (RBD)], Homo sapiens monoclonal antibody, Gamma1 heavy chain Homo sapiens (1-455) [VH (Homo sapiens IGHV3-9*01 (94.9%) -(IGHD) -IGHJ1*01 (90.9%) L123>T (120), CDR-IMGT [8.8.18] (26-33.51-58.97-114)) (1-125) -Homo sapiens IGHG1*03, G1m3, nG1m1Gemifloxacin
go.drugbank.com/drugs/DB01155ApprovedInvestigationalGemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia.
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 Enzyme InhibitorsProducts: Factive film-coated tablet 320 mg, ONFACT 320 MG FİLM TABLET, 5 ADETFINLAY-FR-1
go.drugbank.com/drugs/DB16524Experimentaltrial RPCEC00000332 (Phase I / II, randomized, controlled, adaptive, double-blind and multicenter study to evaluate the safety, reactogenicity and immunogenicity, of the prophylactic FINLAY-FR-1 anti-SARS-CoV … -2 Vaccine Candidate in a two-doses schedule.
Synonyms: FINLAY-FR-1 anti-SARS-CoV-2 vaccine candidateIsavuconazonium
go.drugbank.com/drugs/DB06636ApprovedInvestigationalDue to low solubility in water of isavuconazole on its own, the isovuconazonium formulation is favorable as it has high solubility in water and allows for intravenous administration. … Isovuconazonium has excellent oral bioavailability, predictable pharmacokinetics, and a good safety profile, making it a reasonable alternative to its few other competitors on the market.
Categories: Cytochrome P-450 CYP2B6 Inducers, Cytochrome P-450 SubstratesProducts: CRESEMBA® 200 MG POLVO LIOFILIZADO ESTERIL PARA RECONSTITUIRSuccimer
go.drugbank.com/drugs/DB00566ApprovedInvestigationalA mercaptodicarboxylic acid used as an antidote to heavy metal poisoning because it forms strong chelates with them.
Synonyms: DMS-ACategories: Compounds used in a research, industrial, or household setting