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Rilmenidine
go.drugbank.com/drugs/DB11738ApprovedWithdrawnRilmenidine has been used in trials studying the treatment of Hypertension and Chronic Kidney Disease.
Products: HYPERIUM 1 MG TABLET, 30 ADET, Iterium 1 mg - TablettenPrimidone
go.drugbank.com/drugs/DB00794ApprovedVet approvedPrimidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. … [L11112] Primidone was developed by J Yule Bogue and H C Carrington in 1949.[A189522] Primidone was granted FDA Approval on 8 March 1954.[L11112]
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InducersSynonyms: 5-Phenyl-5-ethyl-Hexahydropyrimidine-4,6-dioneBezafibrate
go.drugbank.com/drugs/DB01393ApprovedInvestigationalAntilipemic agent that lowers cholesterol and triglycerides. It decreases low density lipoproteins and increases high density lipoproteins.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 InhibitorsProducts: BEZAFIBRATO 200 MG, ZAFIBRAL TABLET 200 mgFlutamide
go.drugbank.com/drugs/DB00499ApprovedInvestigationalAn antiandrogen with about the same potency as cyproterone in rodent and canine species.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: α,α,α-trifluoro-2-methyl-4'-nitro-m-propionotoluidideAvobenzone
go.drugbank.com/drugs/DB09495ApprovedInvestigationalAvobenzone has the ability to absorb ultraviolet light over wider range of wavelengths. It is included in many commercially available sunscreens which are used as wide spectrum sunscreens. … Avobenzone has an absorption maximum of 357 nm. Sunscreens containing avobenzone is indicated for providing protection from the sun.
Mixtures: UV Base SPF 50, Mango Bay SPF 50Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesMidostaurin
go.drugbank.com/drugs/DB06595ApprovedInvestigationalIt was approved on April 28, 2017 and has shown to increase the overall survival rate in patients with AML as an adjunct therapy along with chemotherapeutic agents. … It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hematopoietic tumors [A19108].
Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 CYP2B6 InducersProducts: RYDAPT (25 MG SOFT CAPSULES), RYDAPT 25 MG YUMUŞAK KAPSÜL, 112 ADETValbenazine
go.drugbank.com/drugs/DB11915ApprovedInvestigationalThe reduction in chorea severity was observed as early as 2 weeks after starting treatment with an initial dose of 40 mg.[L47910] … [A261165] On April 2017, valbenazine was approved by the FDA under the brand name INGREZZA as the first and only approved treatment for adults with Tardive Dyskinesia (TD).
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: REMLEAS HARD CAPSULES 40 MGTelithromycin
go.drugbank.com/drugs/DB00976ApprovedTelithromycin binds to the 50S subunit of the 70S bacterial ribosome and blocks further peptide elongation. … Binding occurs simultaneously at to two domains of 23S RNA of the 50S ribosomal subunit, domain II and V, where older macrolides bind only to one.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsProducts: KETEK ® 400 MGDobesilic acid
go.drugbank.com/drugs/DB13529InvestigationalProducts: DOXIUM 1000 MG FILM TABLET, 30 ADET, DOXIUM 1000 MG FILM TABLET, 60 ADETChlorambucil
go.drugbank.com/drugs/DB00291ApprovedInvestigationalAlthough it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed) … A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases.
Synonyms: 4-(p-bis(beta-chloroethyl)aminophenyl)butyric acid, 4-(p-bis(β-chloroethyl)aminophenyl)butyric acidProducts: Leukeran 2 mg - Filmtabletten, LEUKERAN 2 MG TABLET, 25 ADET