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Onasemnogene abeparvovec
go.drugbank.com/drugs/DB15528ApprovedInvestigationalOnasemnogene abeparvovec is an adeno-associated virus vector-based gene therapy that has been approved by the FDA in May 2019 for the treatment of infant patients (less than 2 years of age) with spinal … [L9194] Onasemnogene abeparvovec for therapeutic use and marketing is currently being assessed by the EU and an intrathecal formulation of the drug is currently undergoing clinical development in the USA
Tofacitinib
go.drugbank.com/drugs/DB08895ApprovedInvestigationalBesides rheumatoid arthritis, tofacitinib has also been studied in clinical trials for the prevention of organ transplant rejection, and is currently under investigation for the treatment of psoriasis. … Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function.
Categories: Biologics for Rheumatoid Arthritis Treatment, Cytochrome P-450 SubstratesFlibanserin
go.drugbank.com/drugs/DB04908ApprovedInvestigationalin the brain as well as an effect on increasing norepinephrine and dopamine neurotransmitters. … Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015.
Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsRose bengal
go.drugbank.com/drugs/DB11182ApprovedInvestigationalIt is also used in laboratory settings, including the preparation of Foraminifera for microscopic analysis and suppression of bacterial growth in several microbiological media. … The clinical applications of rose bengal as injectable formulation under the name PV-10 in melanoma, breast cancer and skin conditions such as eczema and psoriasis are being investigated in clinical trials
Avacincaptad pegol
go.drugbank.com/drugs/DB15165ApprovedInvestigational[A260801] Although anti-VEGF therapy is available for the neovascular form of AMD, no treatment was approved for GA. … Avacincaptad pegol is an RNA aptamer covalently bound to a branched polyethylene glycol (PEG) molecule.
Spinosad
go.drugbank.com/drugs/DB08823ApprovedVet approvedto many investigations for use in other animals and agricultural plants. … Spinosad has also been experimented for use in cats for treatment of flea infestations, and has also been experimented for use against the KS1 Ctenocephalides felis flea strain infesting dogs, in addition
Mixtures: Comfortis Plus (Spinosad + Milbemycin oxime) Chewable Tablets for Dogs 9.1-18kg, Comfortis Plus (Spinosad + Milbemycin oxime) Chewable Tablets for Dogs 18.1-27kgPargyline
go.drugbank.com/drugs/DB01626ApprovedPargyline is a monoamine oxidase inhibitor with antihypertensive properties.
Categories: MAO Inhibitors and Diuretics, Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substratesEarly Hormone Receptor Positive, HER2/Neu Negative Node Positive Breast Cancer
go.drugbank.com/conditions/DBCOND0143574Drugs: AbemaciclibSynonyms: Early Hormone Receptor Positive, HER2/Neu Negative Node Positive Breast Cancer, Early HER2/Neu Negative, Hormone Receptor Positive node positive Breast CancerFormestane
go.drugbank.com/drugs/DB08905ApprovedWithdrawnIt is listed as a prohibited substance by the World Anti-Doping Agency for use in athletes. … Formestane is also a prohormone of 4-hydroxytestosterone, an active steroid with weak androgenic activity and mild aromatase inhibitor activity.
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersLedipasvir
go.drugbank.com/drugs/DB09027ApprovedThis is an important advantage relative to HCV drugs that target other viral enzymes such as the protease, for which rapid development of resistance has proven to be an important cause of therapeutic failure … More specifically, ledipasvir is an inhibitor of the Hepatitis C Virus (HCV) Non-Structural Protein 5A (NS5A), which is required for viral RNA replication and assembly of HCV virions.
Categories: P-glycoprotein inhibitors, P-glycoprotein substrates