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Miltefosine
go.drugbank.com/drugs/DB09031ApprovedInvestigationalIt can be administered topically or orally and is only indicated in patients aged 12 years or older. … It is currently the only recognized oral agent used to treat visceral, cutaneous, and mucosal forms of leishmaniasis, a neglected tropical disease.
Tocopherol
go.drugbank.com/drugs/DB11251ApprovedInvestigationalThey present strong antioxidant activities, and it is determined as the major form of vitamin E. … [A32436] It is currently under the list of substances generally recognized as safe (GRAS) in the FDA for the use of human consumption.[L2114]
Categories: Vitamin E, tocopherol (vit E)Products: VITAMINA E VCASegesterone acetate
go.drugbank.com/drugs/DB14583ApprovedIt mediates progestational activity 100 times higher than that of [progesterone] [A37092]. … It is commonly sold under the brand names Nestorone and Elcometrine and serves as an active component in hormonal contraceptives.
Sodium lauryl sulfate
go.drugbank.com/drugs/DB00815ApprovedIt usually consists of a mixture of sodium alkyl sulfates, mainly the lauryl. … It is also used in creams and pastes to properly disperse the ingredients and as research tool in protein biochemistry. SLS also has some microbicidal activity.
Flurandrenolide
go.drugbank.com/drugs/DB00846ApprovedIt is usually employed as a cream or an ointment, and is also used as a polyethylene tape with an adhesive. (From Martindale, The Extra Pharmacopoeia, 30th ed, p733)
Dehydrocholic acid
go.drugbank.com/drugs/DB11622ApprovedIt has been used for stimulation of biliary lipid secretion. The use of dehydrocholic acid in over-the-counter products has been discontinued by Health Canada.
Mixtures: Duchol EctPixantrone
go.drugbank.com/drugs/DB06193ApprovedWithdrawnIt is currently being tested in Phase III trials. [2] Although pixantrone has not yet received FDA approval in the United States, it has been granted conditional marketing approval by the European Union … It also inhibits doxorubicinol formation in human myocardium. [3] As a result, it is believed to be less cardiotoxic while still exerting efficacy.
Simeprevir
go.drugbank.com/drugs/DB06290ApprovedWithdrawnAdministered once daily with food, 150mg simeprevir capsule is used in combination with [DB08934] in patients with HCV genotype 1 without cirrhosis for 12 week duration. … Broad use of simeprevir occurred when it was used in combination with a newer drug, [DB08934].
Volanesorsen
go.drugbank.com/drugs/DB15067Approved[L16621] This drug is not commonly prescribed as it is used as an adjunct to diet in patients at high risk for pancreatitis, who have had inadequate response to triglyceride lowering therapy. … [L16621] It is indicated to treat familial chylomicronemia, a genetic condition that prevents breakdown of triglycerides and chylomicrons.
Bempedoic acid
go.drugbank.com/drugs/DB11936ApprovedInvestigational[L12144,L12147] It was developed by Esperion Therapeutics Inc. and approved by the FDA on February 21, 2020.