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Trastuzumab deruxtecan
go.drugbank.com/drugs/DB14962ApprovedInvestigational[A188988] Trastuzumab deruxtecan was developed by Daiichi Sankyo in collaboration with AstraZeneca and was first approved by the FDA in 2019.[L10842] … [L10842] It is classified as an antibody-drug conjugate. The cleavable peptide linker used to bind the antibody and drug in this product distinguishes it from other members of its class.
Pegulicianine
go.drugbank.com/drugs/DB18731ApprovedInvestigational[L50537] Pegulicianine (under the brand name Lumisight) was approved for use by the FDA in April 2024.[L50537,L50547] It received Fast Track and priority review for this indication.[L50547] … Pegulicianine is an optical imaging agent indicated for fluorescence imaging in patients with breast cancer.
Categories: Compounds used in a research, industrial, or household settingCoal tar
go.drugbank.com/drugs/DB11082ApprovedCoal tars are complex and variable mixtures of phenols, polycyclic aromatic hydrocarbons (PAHs), and heterocyclic compounds. … Coal tar is among the by-products when coal is carbonized to make coke or gasified to make coal gas.
Mixtures: PREPARED COAL TAR 5% ET SALICYLIC ACID 2% OINTMENT, Multi-action Denorex 2-IN-1 Dandruff Shampoo + ConditionerProducts: Psoriasin In-Shower Treatment, COAL TAR SOLUTION 10% IN AQUEOUS CREAMNelarabine
go.drugbank.com/drugs/DB01280ApprovedInvestigational), in both adult and pediatric patients whose disease has not responded to or has relapsed following at least two chemotherapy regimens. … [A258719] Nelarabine was first granted accelerated approval by the FDA on October 28, 2005, and was manufactured under the trademark name ARRANON by GlaxoSmithKline.
Betula pendula tar oil
go.drugbank.com/drugs/DB11361ApprovedNutraceuticalThe origin plant, also known as the European white or silver birch, grows mainly in the northern hemisphere. … [L2870] Betula pendula tar oil has been approved for its utilization in over-the-counter product combinations by Health Canada.
Protein S human
go.drugbank.com/drugs/DB13149ApprovedInvestigationalProtein S human is a vitamin K-dependent plasma glycoprotein which has antcoagulant properties [A19561]. It serves as a negative feedback mechanism in the coagulation cascade.
Mixtures: Beriplex P/n 500, Beriplex P/n 1000Vinorelbine
go.drugbank.com/drugs/DB00361ApprovedInvestigationalIt was found that there was 4.3-fold variation in vinorelbine clearance across the cohort, suggesting a strong influence of genetics on the clearance of this drug [L2002]. … A study was done on the clearance rate of vinorelbine on individuals with various single polymorphonuclear mutations.
Lecanemab
go.drugbank.com/drugs/DB14580ApprovedInvestigational[A253962,L44547] On January 6, 2023, lecanemab was granted accelerated approval by the FDA for the treatment of Alzheimer’s Disease.[L44547] It was granted full FDA approval on July 6, 2023. … [A253947,A253957] In clinical trials, it significantly reduced brain Aβ plaques compared to placebo.
Medrogestone
go.drugbank.com/drugs/DB09124ApprovedWithdrawnIt was conceived as an alternative for an orally effective contraceptive option.[A31526] It was developed by Ayerst, approved in Canada in 1969 and its current status is cancelled post-marketing. … [L1118] It was never approved by the FDA.
Aliskiren
go.drugbank.com/drugs/DB09026ApprovedInvestigational[A203624] It was developed by Speedel and Novartis and initially approved by the FDA in early 2007. … [L14018] Aliskiren has been proven to efficacious in reducing blood pressure when used alone or in conjunction with other antihypertensive agents.[A203624]
Categories: Agents Acting on the Renin-Angiotensin System