Coal tar

Identification

Brand Names
Cutar, Dhs Tar Shampoo, Psoriasin, Scytera, Tarsum, Tera Gel
Generic Name
Coal tar
DrugBank Accession Number
DB11082
Background

Coal tar is a brown or black liquid of extremely high viscosity. Coal tar is among the by-products when coal is carbonized to make coke or gasified to make coal gas. Coal tars are complex and variable mixtures of phenols, polycyclic aromatic hydrocarbons (PAHs), and heterocyclic compounds.

It has been indicated for local relief of itching, dryness, and irritation caused by psoriasis, seborrhea and eczema.

Type
Small Molecule
Groups
Approved
Synonyms
  • Coal tar
  • Coal tars
  • Tar, coal

Pharmacology

Indication

Relieving itching, irritation, redness, dryness, scaling, and flaking of the skin caused by psoriasis, seborrhea, or eczema.

Pharmacology
Reduce drug development failure rates
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Associated Conditions
Contraindications & Blackbox Warnings
Contraindications
Avoid life-threatening adverse drug events
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Avoid life-threatening adverse drug events & improve clinical decision support.
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Pharmacodynamics

Decrease bacterial growth.

Mechanism of action

Coal tar ointment is a keratolytic. It works by slowing bacterial growth and loosening and softening scales and crust.

Absorption

Intended for local use only, no systemic absorption.

Volume of distribution

Intended for local use only, no systemic absorption.

Protein binding

Intended for local use only, no systemic absorption.

Metabolism

Intended for local use only, no systemic absorption.

Route of elimination

Intended for local use only, no systemic absorption.

Half-life

Intended for local use only, no systemic absorption.

Clearance

Intended for local use only, no systemic absorption.

Adverse Effects
Adverseeffects
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Toxicity

LD50: Not available.

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

Products2
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International/Other Brands
Estar / Lavatar / Pixalbol
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Advanced Psoriasis TherapySoap5 g/1000gTopicalCVS Health2016-06-10Not applicableUS flag
Anti-DandruffShampoo25 mg/1mLTopicalStrategic Sourcing Services LLC2005-05-21Not applicableUS flag
Assured T And PlusShampoo5 mg/1mLTopicalBicooya Cosmetics Limited2014-01-212020-04-04US flag
Balnetar Liq 2.5%Liquid2.5 %TopicalWestwood Squibb, Division Of Bristol Myers Squibb Canada Inc.1963-12-312009-04-17Canada flag
Coal Tar Anti-dandruff ShampooShampoo0.5 %TopicalVi JonNot applicableNot applicableCanada flag
Coal Tar SolutionLiquid200 g / LTopicalD.C. Labs Limited1951-12-312003-07-11Canada flag
COAL TAR SOLUTION 10% IN AQUEOUS CREAMCream10 % v/wTopicalICM PHARMA PTE. LTD.1989-05-22Not applicable
COAL TAR SOLUTION 15% IN AQUEOUS CREAMCream15 %TopicalICM PHARMA PTE. LTD.1989-05-22Not applicable
COAL TAR SOLUTION 5% IN AQUEOUS CREAMCream5 %TopicalICM PHARMA PTE. LTD.1989-05-22Not applicable
Coal Tar Topical Solution - 20%Solution200 mg / mLTopicalMedisca Pharmaceutique Inc1997-08-282002-07-24Canada flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Alphosyl CreamCoal tar (5.4 %) + Allantoin (2 %)CreamTopicalReed & Carnrick, Division Of Block Drug Company (Canada) Ltd.1961-12-311999-07-05Canada flag
Alphosyl LotionCoal tar (5 %) + Allantoin (2 %)LotionTopicalReed & Carnrick, Division Of Block Drug Company (Canada) Ltd.1958-12-311999-07-05Canada flag
Cera-Scalp OintmentCoal tar (12% w/w) + Octasulfur (4 % w/w) + Salicylic acid (2 % w/w)OintmentTopicalHOE PHARMACEUTICALS SDN. BHD.2020-09-08Not applicableMalaysia flag
ClobetaCoal tar (23 mg/1mL) + Clobetasol propionate (0.5 mg/1g)KitTopicalTiber Laboratories, LLC2011-04-062012-06-30US flag
ClobetaCoal tar (23 mg/1mL) + Clobetasol propionate (0.5 mg/1g)KitTopicalTiber Laboratories, LLC2011-04-062012-06-30US flag
COCOIS CO. OINTMENTCoal tar (10 % w/w) + Camphor (2 % w/w) + Octasulfur (4 % w/w) + Salicylic acid (2 % w/w)OintmentTopicalICM PHARMA PTE. LTD.1989-07-24Not applicable
Denorex Extra Strength Medicated ShampooCoal tar (10.4 %) + Chloroxylenol (0.5 %) + Levomenthol (1.5 %)ShampooTopicalThe Denorex Company1970-12-312007-06-20Canada flag
Denorex Extra Strength Medicated ShampooCoal tar (2.4 % w/w) + Chloroxylenol (0.5 % w/w) + Levomenthol (1.5 % w/w)ShampooTopicalNeoteric Cosmetics Inc.2007-04-20Not applicableCanada flag
Denorex Extra Strength Medicated Shampoo With ConditionersCoal tar (2.4 % w/w) + Chloroxylenol (0.5 % w/w) + Levomenthol (1.5 % w/w)ShampooTopicalNeoteric Cosmetics Inc.2007-04-20Not applicableCanada flag
Denorex Extra Strength Medicated Shampoo With ConditionersCoal tar (10.4 %) + Chloroxylenol (0.5 %) + Levomenthol (1.5 %)ShampooTopicalThe Denorex Company1995-12-312007-06-20Canada flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Clobetasol Propionate 0.05% / Coal Tar 8% / Salicylic Acid 6%Coal tar (8 g/100g) + Clobetasol propionate (0.05 g/100g) + Salicylic acid (6 g/100g)CreamTopicalSincerus Florida, LLC2019-05-15Not applicableUS flag
Pazol XSCoal tar (0.5 mg/1mL) + Octasulfur (20 mg/1mL) + Salicylic acid (20 mg/1mL)ShampooTopicalStratus Pharmaceuticals2011-07-012017-07-31US flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
  • Humans and other mammals

Chemical Identifiers

UNII
R533ESO2EC
CAS number
8007-45-2
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

References

General References
  1. product info [Link]
  2. Doctoralia: Soriderm (allantoin/coal tar) product information [Link]
PubChem Substance
347911108
RxNav
2635
Wikipedia
Coal_tar

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedBasic ScienceGeneral Anesthesia / Loss of Consciousness and Recovery of Consciousness / Propofol Pharmacodynamics / Propofol Plasma Concentration / Propofol Target Controlled Infusion1
4RecruitingBasic SciencePsoriasis (PsO) / Psoriasis Vulgaris (Plaque Psoriasis)1
4Unknown StatusTreatmentDermatitis, Dermatitis Atopic1
3Unknown StatusTreatmentPsoriasis (PsO)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SoapTopical5 g/1000g
LiquidTopical2.5 %
OintmentTopical
KitTopical
ShampooTopical0.5 %
LiquidTopical200 g / L
CreamTopical10 % v/w
CreamTopical15 %
CreamTopical5 %
SolutionTopical200 mg / mL
OintmentTopical2 % w/w
LotionTopical1.5 g/100mL
SolutionTopical10 % w/v
SoapTopical2.13 g/100g
CreamTopical
ShampooTopical0.005 g/1g
LiquidTopical2 %
SolutionTopical2 %
LiquidTopical10 %
GelTopical
LotionTopical20 g/1000g
LotionTopical8 g/1000g
CreamTopical20 g/1000g
CreamTopical10 %
GelTopical5 %
CreamTopical2 g/100g
EmulsionTopical0.5 %
EmulsionTopical1 %
EmulsionUnknown1 %
EmulsionTopical2 %
Shampoo, suspensionTopical0.65 % w/w
ShampooTopical25 % v/v
SolutionTopical20 % w/v
Liquid; shampooTopical2 %
ShampooTopical4.25 %
SolutionTopical10 % w/w
SolutionTopical2 % w/w
EmulsionTopical4 g
CreamTopical.55 g/100g
CreamTopical0.55 g/100g
SoapTopical0.5 % w/w
GelTopical1.25 g / 100 g
OintmentTopical0.03 g/1g
GelTopical0.02 g/1g
OintmentTopical0.02 g/1g
ShampooTopical0.03 g/1g
ShampooTopical1.1 %
LiquidTopical0.5 %
Gel; shampooTopical2 %
GelTopical1.5 %
ShampooTopical10 mg/1mL
ShampooTopical0.50 %
ShampooTopical5 mg/1mL
ShampooTopical2 %
SolutionTopical20 %
LotionTopical10 mg/1mL
ShampooTopical
ShampooTopical1.77441 g/177.441mL
ShampooTopical4.0 %
ShampooTopical4.3 %
ShampooTopical0.5 g/100mL
Lotion / shampooTopical
OintmentTopical5 % w/w
CreamTopical10 mg/1mL
CreamTopical5 mg/1mL
SolutionTopical23 mg/1mL
LiquidTopical23 mg/1mL
OintmentTopical1 g/100mL
LiquidTopical6.6 mg/1mL
CreamTopical12.5 mg/1g
OintmentTopical20 mg/1g
GelTopical1.25 %
GelTopical12.5 mg/1g
Lotion / shampooTopical20 mg/1g
SolutionTopical0.66 %
OintmentTopical2.0 %
CreamTopical5 mg/1g
LiquidTopical0.66 %
CreamTopical1 g/100mL
CreamTopical2.0 %
OintmentTopical2.5 g/100g
OintmentTopical2 mg/100mL
Aerosol, foamTopical20 mg/1g
SolutionTopical
SolutionTopical1 % w/w
ShampooTopical17 mg/1mL
LotionTopical0.5 mg/1mL
EmulsionTopical
LotionTopical
LotionTopical2 g
LiquidTopical7.5 %
ShampooTopical1 %
SolutionTopical0.5 %
LiquidTopical100 %
LotionTopical5 %
GelTopical10 %
ShampooTopical2.5 %
ShampooTopical2 g/100mL
Lotion; shampooTopical1.4 %
ShampooTopical1.4 %
ShampooTopical0.57 g/114mL
ShampooTopical3 %
ShampooTopical1 g/100mL
ShampooTopical1.02 mg/1mL
ShampooTopical10.2 mg/1mL
ShampooTopical2.5 mg/1mL
ShampooTopical0.5 % w/w
ShampooTopical25 mg/1mL
LiquidTopical
LiquidTopical1 %
LiquidTopical3 %
ShampooTopical10 %
ShampooTopical50 mg/1mL
ShampooTopical5 g/100mL
EmulsionTopical30 %
Liquid; shampooTopical
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on December 03, 2015 16:51 / Updated on October 20, 2021 19:48