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Displaying results 1531 - 1540 of 10000 in total
  1. Drug

    Pipamperone

    go.drugbank.com/drugs/DB09286
    Investigational

    Pipamperone is a typical antipsychotic of the _butyrophenone_ family used in the treatment of schizophrenia. … Interestingly, when [risperidone] was created, Janssen suggested it was a more potent version of pipamperone.

    Categories: Dopamine D2 Receptor Antagonists
  2. Drug

    Gedatolisib

    go.drugbank.com/drugs/DB11896
    ApprovedInvestigational

    breast cancer without a PIK3CA mutation detected, following progression on or after at least one line of endocrine therapy in the metastatic setting. … [L63796,L63927] The PI3K/AKT/mTOR pathway is a long-standing target in the breast cancer setting, with previously approved agents acting on a single node of it (i.e. PI3Kα, AKT, or mTORC1).

    Categories: Class I Phosphatidylinositol 3-Kinases, antagonists & inhibitors
  3. Drug

    Elacestrant

    go.drugbank.com/drugs/DB06374
    ApprovedInvestigational

    [L44918,L44948] It received a similar approval in the EU in September 2023. … Elacestrant is a non-steroidal small molecule and an estrogen receptor (ER) antagonist.

  4. Indication

    Facial Skin Wrinkles

    go.drugbank.com/conditions/DBCOND0057699
    Drugs: Botulinum toxin type A
    Synonyms: Lined face
  5. Indication

    Ulceration of the mouth

    go.drugbank.com/conditions/DBCOND0100372
    Drugs: Apremilast · Benzethonium · Benzocaine · Choline salicylate · Dequalinium · Lidocaine +7 more
    Synonyms: Pain in oral cavity
  6. Drug

    Simoctocog alfa

    go.drugbank.com/drugs/DB09108
    Approved

    Simoctocog alfa is a fourth-generation BDD FVIII product made in the human embryonic kidney (HEK) cell line. … It is an antihemorrhagic agent used as a replacement therapy in individuals with Haemophilia A who lack the factor VIII in the intrinsic pathway of blood coagulation system.

    Products: NUWIQ 500 UI, NUWIQ 2000 UI
  7. Drug

    Imipenem

    go.drugbank.com/drugs/DB01598
    ApprovedInvestigational

    [A15389] Imipenem is commonly used in combination with [cilastatin] and is now available in a triple-drug product with cilastatin and [relebactam] which was recently approved by the FDA. … Imipenem is a semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains.

    Synonyms: N-formimidoylthienamycin, N-formimidoyl thienamycinMixtures: IMIPENEM/CILASTATINA POLVO PARA RECONSTITUIR A SOLUCIÓN INYECTABLE, ARZOMEBA PISA 500MG/500MG (IMIPENEM+CILASTATINA) POLVO PARA RECONSTITUIR A SOLUCIÓN INYECTABLE
  8. Drug

    Vanadium

    go.drugbank.com/drugs/DB13971
    Approved

    Mixtures: Multi Plex I - Tab, Multi Plex II - Tab
  9. Drug

    Pegloticase

    go.drugbank.com/drugs/DB09208
    ApprovedInvestigational

    Pegloticase is a porcine recombinant PEGylated uricase indicated for the treatment of chronic gout in adult patients that do not respond to other types of therapies. … [L42425] Pegloticase was approved by the FDA in 2014, and in 2022, the drug label included the co-administration of pegloticase and methotrexate.[L42425]

    Categories: Compounds used in a research, industrial, or household setting
  10. Drug

    Siltuximab

    go.drugbank.com/drugs/DB09036
    ApprovedInvestigational

    Siltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese hamster ovary (CHO) cell line by recombinant DNA technology. … It is administered as a 1 hour intravenous infusion every 3 weeks.