Search
Loncastuximab tesirine
go.drugbank.com/drugs/DB16222ApprovedInvestigationalRelapsed and refractory B-cell acute lymphoblastic leukemia (B-ALL) are a therapeutic challenge for patients who have undergone prior systemic therapies with limited success. Prognosis is poor and more effective therapies are needed to t...
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesMiricorilant
go.drugbank.com/drugs/DB16234InvestigationalMiricorilant is under investigation in clinical trial NCT03818256 (Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Miricorilant (CORT118335) in Obese Adult Patients With Schizophrenia and Recent Weight Gain While Taking An...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C19 SubstratesTL-895
go.drugbank.com/drugs/DB16471InvestigationalTL-895 is a potent, orally active, ATP-competitive, and highly selective irreversible BTK inhibitor with an IC50 and a Ki of 1.5 nM and 11.9 nM, respectively. TL-895 is under investigation in several clinical trials for its safety and ef...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesBirch bark extract
go.drugbank.com/drugs/DB16536ApprovedInvestigationalBirch bark extract is rich in triterpenoids with beneficial biological and pharmacological activities. Some of the compounds identified in it include betulin, lupeol, betulinic acid, oleanolic acid, and erythrodiol. Birch bark extract is...
Categories: Cytochrome P-450 CYP2C8 Inhibitors, Cytochrome P-450 Enzyme InhibitorsElzasonan
go.drugbank.com/drugs/DB18969InvestigationalElzasonan is under investigation in clinical trial NCT00275197 (A Research Study to Compare the Treatments of a Combination of Elzasonan With Zoloft, to Zoloft Alone, or Placebo in People With Major Depressive Disorder (MDD)).
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C19 SubstratesSevasemten
go.drugbank.com/drugs/DB18983InvestigationalSevasemten is under investigation in clinical trial NCT05291091 (Phase 2 Study of EDG-5506 in Becker Muscular Dystrophy (GRAND CANYON)).
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesOSU-6162
go.drugbank.com/drugs/DB19178InvestigationalOSU-6162 is under investigation in clinical trial NCT05641623 (OSU6162 as Add-on in Ssri/snri-resistant Depression).
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsMethylone
go.drugbank.com/drugs/DB19192InvestigationalMethylone is under investigation in clinical trial NCT05741710 (A Study to Assess the use of Methylone in the Treatment of PTSD).
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesSofpironium
go.drugbank.com/drugs/DB19325ApprovedSofpironium is a "soft" anticholinergic analog of glycopyrronium that has been modified with a readily hydrolyzable ester moiety. Soft drugs are designed to reduce systemic toxicity while enhancing local efficacy by employing retrometabo...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 Inhibitors