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Sevasemten

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Identification

Generic Name
Sevasemten
DrugBank Accession Number
DB18983
Background

Sevasemten is under investigation in clinical trial NCT05291091 (Phase 2 Study of EDG-5506 in Becker Muscular Dystrophy (GRAND CANYON)).

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 381.291
Monoisotopic: 381.084887266
Chemical Formula
C16H11F4N5O2
Synonyms
  • 2-[(5-fluoropyridin-3-yl)methyl]-6-[2-(2,2,2- trifluoroethoxy)pyrimidin-5-yl]pyridazin-3(2H)-one
  • Sevasemten
External IDs
  • EDG 5506
  • EDG-5506
  • EDG5506
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
JT5OYR0WUK
CAS number
2417395-15-2
InChI Key
XFPJKQRXBAFXNK-UHFFFAOYSA-N
InChI
InChI=1S/C16H11F4N5O2/c17-12-3-10(4-21-7-12)8-25-14(26)2-1-13(24-25)11-5-22-15(23-6-11)27-9-16(18,19)20/h1-7H,8-9H2
IUPAC Name
SMILES
FC1=CN=CC(CN2N=C(C=CC2=O)C2=CN=C(OCC(F)(F)F)N=C2)=C1

References

General References
Not Available
ChemSpider
128921511

Clinical Trials

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PhaseStatusPurposeConditionsCountStart DateWhy Stopped100+ additional columns
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2Enrolling by InvitationTreatmentBecker's Muscular Dystrophy (BMD)1somestatusstop reasonjust information to hide
2RecruitingTreatmentBecker's Muscular Dystrophy (BMD)1somestatusstop reasonjust information to hide
2RecruitingTreatmentDuchenne Muscular Dystrophy (DMD)2somestatusstop reasonjust information to hide
1CompletedTreatmentBecker's Muscular Dystrophy (BMD)1somestatusstop reasonjust information to hide
1CompletedTreatmentBecker's Muscular Dystrophy (BMD) / Healthy Volunteers (HV)1somestatusstop reasonjust information to hide

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at June 27, 2024 21:23 / Updated at June 28, 2024 04:47