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Putrescine
go.drugbank.com/drugs/DB01917InvestigationalKnown drug targets of putrescine include putrescine-binding periplasmic protein, ornithine decarboxylase, and S-adenosylmethionine decarboxylase proenzyme. … Putrescine is a toxic diamine formed by putrefaction from the decarboxylation of arginine and ornithine. Putrescine is a solid. This compound belongs to the polyamines.
Capivasertib
go.drugbank.com/drugs/DB12218ApprovedInvestigationalname TRUQAP, was approved by the FDA for the treatment of adult patients HR-positive, HER2-negative locally advanced or metastatic breast cancer with one or more alterations in PIK3CA/AKT1/PTEN gene(s) … Therefore, targeting the PIK3/AKT pathway presents a promising approach for the treatment of breast cancer, leading to the development of capivasertib, a pan-AKT kinase inhibitor.
Categories: MATE 1 Inhibitors, MATE 2 InhibitorsBenzimate
go.drugbank.com/drugs/DB05170ExperimentalThe anti-cancer and anti-viral activity of the benzimidazoles was originally investigated by the Proctor & Gamble Company beginning in the 1990's. … Benzimate is the lead compound selected from a series of compounds known as benzimidazoles.
LU-31130
go.drugbank.com/drugs/DB05828ExperimentalLU-31130 is a rapid acting therapy developed by H. Lundbeck A/S to treat Psychosis, Schizophrenia and Schizoaffective Disorders. … It provides anti-psychotic characteristic and a low incidence of extrapyramidal and cardiovascular side effects.
Dexchlorpheniramine
go.drugbank.com/drugs/DB13679InvestigationalDexchlorpheniramine is a potent S-enantiomer of chlorpheniramine. … The salt form dexchlorpheniramine maleate as the active ingredient is available as a prescription drug indicated for adjunctive therapy for allergic and anaphylactic reactions.
Mixtures: CORICIDIN® GOTAS PEDIATRICAS CON ACETAMINOFENCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-Ring1D-myo-inositol 1,4,5-trisphosphate
go.drugbank.com/drugs/DB03401ExperimentalInositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. … Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane.
Synonyms: D-myo-Inositol 1,4,5-trisphosphate, D-myo-Inositol-1,4,5-triphosphateOxaprotiline
go.drugbank.com/drugs/DB09307ExperimentalDextroprotiline is the S or dextro isomer of oxaprotiline (CGP-12,104-A). … Oxaprotiline is a racemic mixture of the isomers levoprotiline and dextroprotiline. Levoprotiline is the R or levo isomer of oxaprotiline (CGP-12,103-A).
INO-4800
go.drugbank.com/drugs/DB15693InvestigationalINO-4800 is a DNA vaccine containing the full sequence for the SARS-CoV-2 Spike (S) protein in development for immunization against COVID-19. … [A214475] Early _in vitro_ studies using HEK-293T cells demonstrated that the transfection of INO-4800 results in the expression of S protein by human cells.
Exagamglogene autotemcel
go.drugbank.com/drugs/DB15572ApprovedInvestigationalSickle cell disease (SCD) is a genetic disorder characterized by the production of abnormal sickle-shaped red blood cells (called hemoglobin S, HbS) that initiate a pathophysiology resulting in severe … mainstay of treatment since the 1990s - as well as newer agents like [crizanlizumab] and [voxelotor].
Synonyms: gene editing consisting of a guide RNA (gRNA), Autologous CD34+ cells isolated from mobilised peripheral blood by positive selection, modified by CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9) mediatedLNP-nCoVsaRNA Vaccine
go.drugbank.com/drugs/DB15799ExperimentalLNP-nCoVsaRNA is a purified, synthetic mRNA vaccine candidate encoding the S glycoprotein of SARS-CoV-2, which is used primarily by the virus to attach to and invade human cells. … As of July 2020, a clinical trial (COVAC1) is underway (ISRCTN17072692) to test the safety and immunogenicity of the vaccine.