Oxaprotiline

DB09307ExperimentalSmall molecule

Oxaprotiline is a norepinephrine reuptake inhibitor of the tetracyclic antidepressant family that is related to maprotiline. This drug was never marketed. Oxaprotiline is a racemic mixture of the isomers levoprotiline... Levoprotiline is the R or levo isomer of oxaprotiline (CGP-12,103-A).

Mechanism: Pharmacologically active on Sodium-dependent noradrenaline transporter
Curator reviewed
Primary indication: Investigated for the treatment of depression.Curator reviewed
Formula / weight: C₂₀H₂₃NO · 293.41 g/mol (avg)
Also known as: Hydroxymaprotiline

Resolves to

Compound

UNII3V3Z2HK4LSCAS56433-44-4ChEMBLCHEMBL1213009

Structure

InChIKeyFDXQKWSTUZCCTM-UHFFFAOYSA-NSMILESCNCC(O)CC12CCC(C3=CC=CC=C13)C1=CC=CC=C21

Targets

P23975SLC6A2P28335HTR2C

What you can answer from here — as of July 03, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1,354Drug interactionsStructured to mechanism, not free text

2+ReferencesStructured and connected to the statements they support

Which drugs share a target with Oxaprotiline, and which of those have an active Phase 3 trial?

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