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Eteplirsen
go.drugbank.com/drugs/DB06014ApprovedInvestigationalEteplirsen is a synthetic antisense oligonucleotide and a phosphorodiamidate morpholino oligomer. … It consists of a six-membered morpholino ring replacing the five-membered ribofuranosyl rings found in natural DNA and RNA.
Synonyms: (P-deoxy-P-(dimethylamino)](2',3'-dideoxy-2',3'-imino-2',3'-seco)(2'a→5')(C-m5U-C-C-A-A-C-A-m5U-C-A-A-G-G-A-A-G-A-m5U-G-G-C-A-m5U-m5U-m5U-C-m5U-A-G),5'-(P-(4-((2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)carbonyl, )-1-piperazinyl)-N,N-dimethylphosphonamidate) RNACategories: Heterocyclic Compounds, 1-Ring, Compounds used in a research, industrial, or household settingIloperidone
go.drugbank.com/drugs/DB04946ApprovedInvestigationalIloperidone is a benzisoxazole [A263557] and an atypical antipsychotic agent that was first approved by the FDA on May 6, 2009. … [A3024] It is considered to be a second-generation antipsychotic drug [A263552] with multiple receptor binding profile, although it shows high affinity towards 5-HT<sub>2A</sub> and dopamine D2 receptors
Synonyms: 1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1- piperidinyl]propoxy]-3-methoxyphenyl]ethanone, 4'-(3-(4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino)propoxy)-3'-methoxyacetophenoneCategories: Cytochrome P-450 Substrates, Adrenergic alpha-1 Receptor AntagonistsDengue virus serotype 4
go.drugbank.com/drugs/DB22667ApprovedDengue virus serotype 4 is a serotype of _Orthoflavivirus denguei_ known to cause dengue fever. … [A274008] It is one of four serotypes covered by Qdenga, a live, attenuated, tetravalent vaccine used for the prevention of dengue disease.
Synonyms: Dengue virus type 4, Dengue virus serotype 4Ursodeoxycholic acid
go.drugbank.com/drugs/DB01586ApprovedInvestigationalUrsodeoxycholic acid (UDCA), also known as ursodiol, is a naturally-occurring bile acid that constitutes a minor fraction of the human bile acid pool. … [A256267,A256463] UDCA was first characterized in the bile of the Chinese black bear and is formed by 7b-epimerization of [chenodeoxycholic acid], which is a primary bile acid.
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 Enzyme InducersProducts: T-RUXICO, Ursodiol CPolysorbate 80
go.drugbank.com/drugs/DB11063ApprovedInvestigationalPolysorbate 80 is a hydrophilic nonionic surfactant. It is utilized as a surfactant in soaps and cosmetics and also as a lubricant in eye drops. … A substance that would not normally dissolve in a particular solution is able to dissolve with the use of a solubilizing agent.
Mixtures: i-Drops ARTIFICIAL TEARS, ENDURA® UDCategories: P-glycoprotein inhibitors, Cytochrome P-450 CYP3A InhibitorsLumateperone
go.drugbank.com/drugs/DB06077ApprovedInvestigationalSchizophrenia is a complex mental illness and impacts approximately 1% of the population. … [A189093] Lumateperone is a newly approved 2nd generation antipsychotic currently indicated for the treatment of schizophrenia.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesTerazosin
go.drugbank.com/drugs/DB01162ApprovedInvestigationalTerazosin is a quinazoline derivative alpha-1-selective adrenergic blocking agent indicated for benign prostatic hyperplasia and hypertension[FDA Label][A176831]. … Terazosin blocks adrenaline's action on alpha-1 adrenergic receptors, causing relaxation of smooth muscle in blood vessels and the prostate[A176837].
Mixtures: Hytrin-7 Tabs 1mg-7 Tabs 2mg-14 Tabs 5mg, Hytrin-7 Tabs 1mg-7 Tabs 2mg-14 Tabs 5mgCategories: P-glycoprotein inhibitors, Peripheral alpha-1 blockersOteracil
go.drugbank.com/drugs/DB03209ApprovedInvestigationalThe main active ingredient in Teysuno is [DB09256], a pro-drug of [DB00544] (5-FU), which is a cytotoxic anti-metabolite drug that acts on rapidly dividing cancer cells. … It functions by blocking the enzyme orotate phosphoribosyltransferase (OPRT), which is involved in the production of 5-FU.
Categories: Heterocyclic Compounds, 1-RingSynonyms: 5-azaorotic acidBenzonatate
go.drugbank.com/drugs/DB00868Approved[A5790] Currently, benzonatate is the only non-narcotic antitussive available as a prescription drug. … [L11193] Although it not prone to drug misuse or abuse, benzonatate is associated with a risk for severe toxicity and overdose, especially in children.[A189513]
Synonyms: 2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-butylaminobenzoate, p-butylaminobenzoic acid ω-O-methylnonaethyleneglycol esterProducts: D-TATOFexofenadine
go.drugbank.com/drugs/DB00950ApprovedInvestigational[L4269] It is selective for the H<sub>1</sub> receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier[L10779] - this is in contrast to previous first-generation … [A1452] Fexofenadine is the major active metabolite of [terfenadine][A1495] and is administered as a racemic mixture in which both enantiomers display approximately equivalent antihistamine activity.
Synonyms: 4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-alpha,alpha-dimethylbenzeneacetic acidMixtures: ALERMED® D, FEXU D® SUSPENSION