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Triamterene Action Pathway
smpdb.ca/view/SMP0000132Drug actionThis primarily contributes to an increase in sodium excretion and consequentially, fluid excretion which decreases blood volume and blood pressure. … Specifically, triamterene inhibits amiloride-sensitive sodium channels which are responsible for the reabsorption of sodium in the late distal convoluted tubule in the nephron.
Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBATSpironolactone Action Pathway
smpdb.ca/view/SMP0000134Drug actionAldosterone increases sodium reabsorption and potassium excretion by up-regulating the expression of basolateral sodium-potassium ATPases as well as luminal (apical) sodium and potassium channels. … Spironolactone inhibits sodium and water reabsorption as well as potassium excretion by blocking the actions of aldosterone as described above.
Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBATIminoglycinuria
smpdb.ca/view/SMP0000193DiseaseThis disorder is characterized by a large accumulation of glycine, proline, and hydroxyproline in the urine. Symptoms of the disorder include urolithiasis and mental retardation. … SLC36A2 codes for a proton-coupled amino acid transporter which facilitates the reuptake of glycine, proline, and hydroxyproline.
Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBATGlucose Transporter Defect (SGLT2)
smpdb.ca/view/SMP0000245DiseaseThis defect causes massive accumulation of glucose in the urine, and symptoms include glucosuria. … reabsorptive mechanism for D-glucose in the kidney is known to involve a lower affinity, high capacity Na()/glucose cotransporter, which is located in the early proximal convoluted tubule segment S1 and
Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBATBlue Diaper Syndrome
smpdb.ca/view/SMP0000583DiseaseTreatment can include a calcium restricted diet in order to prevent hypercalcemia, and a tryptophan restricted diet to prevent all systems. … Other symptoms can include bacterial infections, damage to various parts of the eye, hypercalcemia, and impaired kidney function due to this.
Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBATLysinuric Protein Intolerance (LPI)
smpdb.ca/view/SMP0000585DiseaseIt is caused by a mutation in the SLC7A7 gene which encodes the Y+L amino acid transporter 1 protein, which is involved in the uptake of amino acids, both with sodium for neutral amino acids, and without … Symptoms of the disorder include failure to thrive after weaning, nausea and vomiting following a meal containing large amounts of protein, as well as osteoporosis, and lung and kidney problems.
Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBATPolythiazide Action Pathway
smpdb.ca/view/SMP0000080Drug actionSolute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … Solute carrier family 12 member 3 is also used for sodium reabsorption that count for 5% of total amount.
Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBATBendroflumethiazide Action Pathway
smpdb.ca/view/SMP0000090Drug actionSolute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … Solute carrier family 12 member 3 is also used for sodium reabsorption that count for 5% of total amount.
Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBATQuinethazone Action Pathway (old)
smpdb.ca/view/SMP0000091Drug actionThe short term mechanism of action is relatively well-understood: thiazides inhibit sodium-chloride co-transport into the renal distal convoluted tubule of the nephron and therefore increase fluid loss … In the case of quinethazone, it inhibits the sodium-chloride symporter, solute carrier family 12 member 3. Thiazides also inhibit sodium ion transport.
Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBATEthacrynic Acid Action Pathway
smpdb.ca/view/SMP0000097Drug actionEtacrynic acid (also known as ethacrynic acid and Edecrin) is a loop diuretic that can inhibit water reabsorption by binding and inhibiting solute carrier family 12 member 1 (also known as sodium-potassium-chloride … Binding of the transporter can prevent import of sodium from lumen from loop of Henle to basolateral interstitium, which lead to more hypertonic environment in lumen than interstitium, and result in prevention
Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBAT