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Mipomersen
go.drugbank.com/drugs/DB05528ApprovedMipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. … Mipomersen is indicated in patients with homozygous familial hypercholesterolemia as an adjunct to diet and other lipid-lowering medications.
Categories: Compounds used in a research, industrial, or household settingAnethole trithione
go.drugbank.com/drugs/DB13853ApprovedAnethole trithione (ATT) appears to have a broad range of unique functions, from increasing salivary secretion to help treat xerostomia [A27165, A32618, A32620, A32621], to demonstrating an ability to … inhibit carcinogenesis by increasing the activity of electrophile detoxification enzymes [A32619], and even being used as an adjunctive therapy for cholecystitis, gallstone, indigestion, and acute/chronic
Tofacitinib
go.drugbank.com/drugs/DB08895ApprovedInvestigationalTofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. … Known adverse effects include nausea and headache as well as more serious immunologic and hematological adverse effects. Tofacitinib is marketed under the brand name Xeljanz by Pfizer.
Selenic acid
go.drugbank.com/drugs/DB11068ApprovedIt may be found in over-the-counter daily dietary supplements as a source of [DB11135], an essential trace mineral for human health. … Selenic acid is an organic compound with the chemical formula H2SeO4.
Mixtures: One-A-day Advance Men's, Beta A With Vitamins C and E Plus SeleniumCategories: Compounds used in a research, industrial, or household settingTolcapone
go.drugbank.com/drugs/DB00323ApprovedInvestigationalWithdrawnTolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase (COMT). It is used in the treatment of Parkinson's disease as an adjunct to levodopa/carbidopa medication. … It is a yellow, odorless, non-hygroscopic, crystalline compound. Tolcapone is associated with a risk of hepatotoxicity.
Anisindione
go.drugbank.com/drugs/DB01125ApprovedAnisindione is a synthetic anticoagulant and an indanedione derivative. … well as the anticoagulant proteins C and S, in the liver.
Benralizumab
go.drugbank.com/drugs/DB12023ApprovedInvestigationalIt is an afucosylated IgG which gives it high affinity for the FcγRIIIα receptor in natural killer cells, macrophages and neutrophils. … Benralizumab is a humanized recombinant monoclonal antibody of the isotype IgG1k immunoglobulin that specifically binds to the alpha chain of the interleukin 5 receptor (IL-5R) expressed on eosinophils
Categories: Interleukin-5 Receptor alpha-directed Cytolytic Antibody, Interleukin 5 Receptor alpha-directed Antibody InteractionsOteracil
go.drugbank.com/drugs/DB03209ApprovedInvestigationalThe main active ingredient in Teysuno is [DB09256], a pro-drug of [DB00544] (5-FU), which is a cytotoxic anti-metabolite drug that acts on rapidly dividing cancer cells. … Oteracil is an adjunct to antineoplastic therapy, used to reduce the toxic side effects associated with chemotherapy.
DL-Methylephedrine
go.drugbank.com/drugs/DB11278ApprovedMethylephedrine is a sympathomimetic amine that appears in various over-the-counter cough and cold medications throughout the world [L2838], [L2839], [L2840].
Categories: Adrenergic alpha-2 Receptor AgonistsNeratinib
go.drugbank.com/drugs/DB11828ApprovedInvestigationalNeratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Human epidermal growth factor receptor 2 (HER2) tyrosine kinase inhibitors