Methylephedrine is a sympathomimetic amine that appears in various over-the-counter cough and cold medications throughout the world , , . The abuse of methylephedrine-containing medications has been reported in Japan.... Methylephedrine is not legally available in the United States, but has been identified in cases of drug abuse.
- Mechanism
- Curator reviewed · 3 references
The pharmacology of methylephedrine is similar to that of other members of the ephedra alkaloid class of drugs. These compounds are sympathomimetic amines because they mimic the effects of the catecholamines on the sympathetic nervous system. These alkaloids permeate the blood-brain barrier and have a direct central nervous system stimulant effect with peripheral effects; the peripheral effects are indirect and primarily mediated by norepinephrine release.
Methylephedrine expands the bronchia by relaxing the bronchial muscles.
The decrease in urination with sympathomimetic use is increased through activation of the alpha-adrenoceptors of the smooth muscles of the bladder.
- Primary indication
- Used as an antitussive and decongestant.Curator reviewed · 9 structured indications
- Formula / weight
- C11H17NO · 179.263 g/mol (avg)
- Also known as
- (+/-)-Methylephedrine · Methylephedrine, (+/-)- · Methylephedrine, DL- · N-methylephedrine DL-form
Resolves to
FMCGSUUBYTWNDP-ONGXEEELSA-NSMILESC[C@@H]([C@H](O)C1=CC=CC=C1)N(C)CWhat you can answer from here — as of August 30, 2026
Which drugs share a target with DL-Methylephedrine, and which of those have an active Phase 3 trial?
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