Anisindione is a synthetic anticoagulant and an indanedione derivative. Its anticoagulant action is mediated through the inhibition of the vitamin K-mediated gamma-carboxylation of precursor proteins that are critical in forming...
- Mechanism
- Curator reviewed
Like phenindione, to which it is related chemically, anisindione exercises its therapeutic action by reducing the prothrombin activity of the blood. By inhibiting the vitamin K–mediated gamma-carboxylation of precursor proteins, the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagulant proteins C and S is prevented. Anisindione has no direct thrombolytic effect and does not reverse ischemic tissue damage, although it may limit extension of existing thrombi and prevent secondary thromboembolic complications.
- Primary indication
- For the prophylaxis and treatment of venous thrombosis and its extension, the treatment of atrial fibrillation with embolization, the prophylaxis and treatment of pulmonary embolism, and as an adjunct in the treatment of coronary occlusion.Curator reviewed
- Formula / weight
- C16H12O3 · 252.2647 g/mol (avg)
- Also known as
- Anisin indandione
Resolves to
XRCFXMGQEVUZFC-UHFFFAOYSA-NSMILESCOC1=CC=C(C=C1)C1C(=O)C2=CC=CC=C2C1=OWhat you can answer from here — as of September 12, 2026
Which drugs share a target with Anisindione, and which of those have an active Phase 3 trial?
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