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Chlorthalidone
go.drugbank.com/drugs/DB00310ApprovedInvestigationalChlorthalidone is a thiazide-like diuretic used for the treatment of hypertension and for management of edema caused by conditions such as heart failure or renal impairment. … [A176324] Chlorthalidone is considered first-line therapy for management of uncomplicated hypertension as there is strong evidence from meta-analyses that thiazide diuretics such as chlorthalidone reduce
Categories: Antihypertensive Agents Indicated for HypertensionLithium cation
go.drugbank.com/drugs/DB01356ApprovedInvestigationalWithdrawnIt is also sometimes prescribed as a preventive treatment for migraine disease and cluster headaches. … The active principle in these salts is the lithium ion Li+, which having a smaller diameter, can easily displace K+ and Na+ and even Ca+2, in spite of its greater charge, occupying their sites in several
Ivosidenib
go.drugbank.com/drugs/DB14568ApprovedInvestigational[A248745] Ivosidenib was granted accelerated approval by the FDA in July 2018 for the treatment of relapsed of refractory acute myeloid leukemia in adults. … [L48781] In February 2023, the EMA's Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion of ivosidenib and recommended it be granted marketing authorization for the treatment
Chronic Myelogenous Leukemia (CML)
go.drugbank.com/conditions/DBCOND0040386Synonyms: Chronic myelogenous leukemia, no International Classification of Diseases for Oncology subtypeIndalpine
go.drugbank.com/drugs/DB08953ApprovedWithdrawnHowever, after the emergence of widespread concern regarding adverse effects caused by SSRIs, and reported hematological effects caused by Indalpine, it was abruptly withdrawn from the US market. … It was initially marketed by Pharmuka.
Sodium oxybate
go.drugbank.com/drugs/DB09072ApprovedInvestigational[L30598] It is a sodium salt of [gamma-Hydroxybutyric acid], an endogenous cerebral inhibitory neurotransmitter [A251445] and a metabolite of the inhibitory neurotransmitter GABA. … [A251430] Due to its physiological effects, sodium oxybate is associated with a risk for substance misuse and abuse.
Molnupiravir
go.drugbank.com/drugs/DB15661Investigational[A193014,A193026] With improved oral bioavailability in non-human primates, it is hydrolyzed _in vivo_, and distributes into tissues where it becomes the active 5’-triphosphate form. … Molnupiravir (EIDD-2801, MK-4482) is the isopropylester prodrug of [N4-hydroxycytidine].
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UsePoliovirus type 1 antigen (formaldehyde inactivated)
go.drugbank.com/drugs/DB10795ApprovedInvestigationalThe vaccine contains purified and inactivated poliovirus type 1 that were grown from a continuous line of monkey kidney cells. … caused by poliovirus Type 1.
Mixtures: Polio Salk "Merieux" - Fertigspritze, Hexaxim Suspension for InjectionPoliovirus type 3 antigen (formaldehyde inactivated)
go.drugbank.com/drugs/DB10797ApprovedInvestigationalThe vaccine contains purified and inactivated poliovirus type 3 that were grown from a continuous line of monkey kidney cells. … caused by poliovirus Type 3.
Mixtures: Polio Salk "Merieux" - Fertigspritze, Hexaxim Suspension for InjectionGalactose
go.drugbank.com/drugs/DB11735ApprovedInvestigationalWithdrawnThere are even proposals for its use in accelerating senescence in mice, rats, and Drosophila, for its association with ovarian cancer, or even for the potential treatment of focal segmental glomerulosclerosis … Nevertheless, none of these ongoing studies have yet provided formal elucidation for their proposals. As a naturally occurring sugar, it may be found in a number dairy products.
Categories: Tests for Liver Functional Capacity