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All 2,870
Drugs 2,860
Targets 0
Indications 10
Pathways 0

Displaying results 1631 - 1640 of 2870 in total

Drug
Ofloxacin
go.drugbank.com/drugs/DB01165
ApprovedInvestigational
A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 Enzyme Inhibitors
Drug
Arsenic trioxide
go.drugbank.com/drugs/DB01169
ApprovedInvestigational
Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic ...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 CYP3A Inhibitors
Drug
Escitalopram
go.drugbank.com/drugs/DB01175
ApprovedInvestigational
Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic citalopram. It is used to restore serotonergic function in the treatment of depression and anxiety. Escitalopram is approximately 150 times ...
Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates
Drug
Idarubicin
go.drugbank.com/drugs/DB01177
ApprovedInvestigational
An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 Substrates
Drug
Ifosfamide
go.drugbank.com/drugs/DB01181
ApprovedInvestigational
Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 Substrates
Drug
Propafenone
go.drugbank.com/drugs/DB01182
ApprovedInvestigational
An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates
Drug
Domperidone
go.drugbank.com/drugs/DB01184
ApprovedInvestigationalVet approved
A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates
Drug
Nadolol
go.drugbank.com/drugs/DB01203
ApprovedInvestigational
Nadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure. Nonselective beta adrenal receptor blockers may no longer be first line in the treatment of hypertension as newer generations of beta adrenal r...
Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates
Drug
Sparfloxacin
go.drugbank.com/drugs/DB01208
ApprovedWithdrawn
Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA top...
Categories: P-glycoprotein substrates, Cytochrome P-450 CYP1A2 Inhibitors
Drug
Metipranolol
go.drugbank.com/drugs/DB01214
ApprovedWithdrawn
A beta-adrenergic antagonist effective for both beta-1 and beta-2 receptors. It is used as an antiarrhythmic, antihypertensive, and antiglaucoma agent.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 Substrates