Ifosfamide is an alkylating and immunosuppressive agent used in chemotherapy for the treatment of cancers, including testicular cancer, ovarian cancer, cervical cancer, osteocarcinoma, bladder cancer, small cell lung cancer, and non-Hodgkin's lymphoma. Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide.
- Mechanism
- Curator reviewed
The exact mechanism of ifosfamide has not been determined, but appears to be similar to other alkylating agents. Ifosfamide requires biotransformation in the liver by mixed-function oxidases (cytochrome P450 system) before it becomes active. After metabolic activation, active metabolites of ifosfamide alkylate or bind with many intracellular molecular structures, including nucleic acids. The cytotoxic action is primarily through the alkylation of DNA, done by attaching the N-7 position of guanine to its reactive electrophilic groups. The formation of inter and intra strand cross-links in the DNA results in cell death.
- Primary indication
- Used as a component of various chemotherapeutic regimens as third-line therapy for recurrent or refractory germ cell testicular cancer.Curator reviewed · 13 structured indications
- Formula / weight
- C7H15Cl2N2O2P · 261.086 g/mol (avg)
- First approval
- Canada, 2002 · United States, 1988
- Also known as
- Iphosphamide · Isofosfamide · Isophosphamide · Isosfamide
- Code names
- Asta Z-4942 · MJF-9325 · NSC-109724 · Z-4942
- Brand names
Resolves to
HOMGKSMUEGBAAB-UHFFFAOYSA-NSMILESClCCNP1(=O)OCCCN1CCClWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Ifosfamide, and which of those have an active Phase 3 trial?
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