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Darunavir
go.drugbank.com/drugs/DB01264ApprovedInvestigational[L9227] Darunavir is being studied as a possible treatment for SARS-CoV-2, the coronavirus responsible for COVID-19, due to in vitro evidence supporting its ability to combat this infection. … Darunavir is a protease inhibitor used with other HIV protease inhibitor drugs as well as [ritonavir] for the effective management of HIV-1 infection.
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseDoxecitine
go.drugbank.com/drugs/DB02594ApprovedInvestigationalIt is an essential component of the deoxyribonucleotide pool required for DNA synthesis and repair. … This combination is the first and only approved treatment for Thymidine Kinase 2 deficiency.[L54613, L54618]
Nitazoxanide
go.drugbank.com/drugs/DB00507ApprovedInvestigationalVet approvedNitazoxanide is a first-line, standard treatment for illness caused by C. parvum or G. lamblia infection in healthy (not immunosuppressed) adults and children and may also be considered in the treatment … of illnesses caused by other protozoa or helminths [A31976].
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseTemazepam
go.drugbank.com/drugs/DB00231Approvedobtain the necessary rest required for medical recovery or scheduled maneuvers and operations [A175339]. … Although the chemical synthesis of temazepam was established by 1965 [A175333], mainstream contemporary use of the medication did not occur until it's legitimate use as treatment for insomnia was accepted
Topiramate
go.drugbank.com/drugs/DB00273ApprovedInvestigationalIn 2004, topiramate was approved for the prevention of migraine in adults. … [A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults.
Products: NABIAN-KFavipiravir
go.drugbank.com/drugs/DB12466ApprovedInvestigational[A191688,A191721] The antiviral targets RNA-dependent RNA polymerase (RdRp) enzymes, which are necessary for the transcription and replication of viral genomes. … Discovered by Toyama Chemical Co., Ltd. in Japan, favipiravir is a modified pyrazine analog that was initially approved for therapeutic use in resistant cases of influenza.
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseHaloprogin
go.drugbank.com/drugs/DB00793ApprovedWithdrawnHaloprogin is a halogenated phenolic ether administered topically for dermotaphytic infections. … Commonly these infections are named for the body part affected, including tinea corporis (general skin), tinea cruris (groin), and tinea pedis (feet).
Categories: Antifungals for Topical Use, Antifungals for Dermatological UseCastor oil
go.drugbank.com/drugs/DB11113ApprovedNutraceuticalVet approvedIt is an FDA-approved food additive directly added to food products for human consumption. … It can also be found in hard candies as a release agent and anti-sticking agent, or supplementary vitamins and mineral oral tablets as an ingredient for protective coatings.
Categories: Drugs for ConstipationEnalapril
go.drugbank.com/drugs/DB00584ApprovedInvestigationalVet approvedThe active metabolite enalaprilat is also available in oral tablets and intravenous formulations for injection. … It is also found in a combination product containing [hydrochlorothiazide] that is used for the management of hypertension.
Categories: Antihypertensive Agents Indicated for HypertensionSelumetinib
go.drugbank.com/drugs/DB11689ApprovedInvestigational[A193611] However, selumetinib demonstrated impressive efficacy and tolerability in Phase I trials, leading to its continued investigation for the treatment of various types of tumours in Phase II trials … [A193611] "The novel MEK 1/2 inhibitor, selumetinib, was initially approved solely for the treatment of pediatric patients with Neurofibromatosis type 1 (NF-1) and symptomatic, inoperable plexiform