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Lifitegrast
go.drugbank.com/drugs/DB11611ApprovedInvestigationalIt is a tetrahydroisoquinoline derivative and lymphocyte function-associated antigen-1 ( LFA-1) antagonist that was discovered through the rational design process. … The ophthalmic solution was approved in July, 2016 under the trade name Xiidra.
Categories: Compounds used in a research, industrial, or household settingTalimogene laherparepvec
go.drugbank.com/drugs/DB13896ApprovedInvestigationalIt specifically replicates within tumor cells and causes lysis. It was approved by the FDA in 2015 under the market name Imlygic. … Talimogene laherparepvec is an oncolytic treatment used in local treatment of unresectable cutaneous, subcutaneous, and nodal lesions in patients with recurrent melanoma.
Lumacaftor
go.drugbank.com/drugs/DB09280ApprovedInvestigationalLumacaftor is a drug used in combination with [DB08820] as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. … [A20301] When used in combination with [DB08820] as the fixed dose combination product Orkambi, lumacaftor is specific for the management of CF in patients with delta-F508 mutations as it acts as a protein-folding
Synonyms: 3-(6-{[1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)cyclopropane-1-carbonyl]amino}-3-methylpyridin-2-yl)benzoic acidHoney
go.drugbank.com/drugs/DB14242ApprovedInvestigationalHoney is an animal extract used in some OTC (over-the-counter) products. It is not an approved drug.
Mixtures: OilInfluenza A virus A/Brisbane/02/2018 (H1N1) recombinant hemagglutinin antigen
go.drugbank.com/drugs/DB15517ApprovedWithdrawnthat it was previously exposed to. … The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses.
Mixtures: FluQuadri Quadrivalent Influenza Vaccine, 0.25 ml, FluQuadri Quadrivalent Influenza Vaccine, 0.5 mlPralsetinib
go.drugbank.com/drugs/DB15822ApprovedInvestigationalIt is currently marketed under the brand name GAVRETO™ by Blueprint Medicines.[L15986] … Although multikinase inhibitors, including [cabozantinib], [ponatinib], [sorafenib], [sunitinib], and [vandetanib], have shown efficacy in RET-driven cancers, their lack of specificity is generally associated
Gallium nitrate
go.drugbank.com/drugs/DB05260ApprovedInvestigationalGallium nitrate is a nitrate salt of [DB14524], a heavy metal that has been used as a diagnostic agent.[A260816] Gallium nitrate is reported to possess antiresorptive and hypocalcemic effects on bone. … [L47726] Apart from cancer-related hypercalcemia, gallium nitrate has been studied in arthritis, autoimmune disorders, and tumours.[A260830]
Velmanase alfa
go.drugbank.com/drugs/DB12374ApprovedInvestigational[A244509] In February 2023, the FDA also approved velmanase alfa for the same indication.[L45295] Velmanase alfa is currently not approved in Canada. … Patients with alpha-mannosidosis have a genetic mutation that causes a deficiency in the lysosomal enzyme alpha-mannosidase, which is an enzyme responsible for breaking down complex sugars in the body.
Rurioctocog alfa pegol
go.drugbank.com/drugs/DB16007ApprovedInvestigationalIt was first approved by the European Commission in January 2018. … [A245149] Hemophilia A is the most common inherited bleeding disorder leading to deficiency of factor VIII, which is caused by defects in the F8C gene that encodes coagulation factor VIII.
Difluocortolone
go.drugbank.com/drugs/DB09095ApprovedWithdrawnDifluocortolone is a potent topical corticosteroid. It is commonly used in dermatology for the reduction of inflammation and itching. … It was submitted to the FDA in July 1984 by the pharmaceutical company Schering AG.[L1082]