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Tranexamic acid
go.drugbank.com/drugs/DB00302ApprovedInvestigationalTranexamic acid is a synthetic derivative of [lysine] used as an antifibrinolytic in the treatment and prevention of major bleeding. … It possesses a similar mechanism of action to [aminocaproic acid] but is approximately 10-fold more potent.
Midostaurin
go.drugbank.com/drugs/DB06595ApprovedInvestigationalMidostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. … It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hematopoietic tumors [A19108].
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexLacidipine
go.drugbank.com/drugs/DB09236ApprovedLacidipine is a lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity. … beta-blocker) and enalapril (an ACE inhibitor) [A31536].
Ublituximab
go.drugbank.com/drugs/DB11850ApprovedInvestigationalCD20, an antigen expressed by various B and T cells, is an attractive therapeutic target in various cancers and autoimmune conditions. … [A244210] Ublituximab is a chimeric anti-CD20 IgG1κ antibody produced in the rat YB2/0 cell line to target a unique epitope and enhance ADCC compared to other approved anti-CD20 antibodies such as [rituximab
Categories: Leukemia, Lymphocytic, Chronic, B-Cell, drug therapyBoceprevir
go.drugbank.com/drugs/DB08873ApprovedWithdrawnBoceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). … Boceprevir is an inhibitor of NS3/4A, a serine protease enzyme, encoded by HCV genotypes 1 and 4 [synthesis].
Amoxapine
go.drugbank.com/drugs/DB00543ApprovedSee toxicity section below for a complete listing of side effects. … They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, amoxapine does not affect mood or arousal, but may cause sedation.
Synonyms: 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepineCategories: Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic IndexAncrod
go.drugbank.com/drugs/DB05099ApprovedWithdrawnAncrod, marketed as Viprinex, is a defibrinogenating agent derived from Malayan pit viper venom. The defribrinogenation of blood results in an anticoagulant effect. … Currently, Viprinex®/ancrod is not approved or marketed in any country, but is being investigated as a stroke treatment in worldwide clinical trials. In January 2005, the U.S.
Categories: Venombin AMethimazole
go.drugbank.com/drugs/DB00763ApprovedInvestigationaloptions such as surgery or radioactive iodine therapy are inappropriate. … [A184559,A184733,A184694] It was first introduced as an antithyroid agent in 1949[A184502] and is now commonly used in the management of hyperthyroidism, particularly in those for whom more aggressive
Delandistrogene moxeparvovec
go.drugbank.com/drugs/DB16802ApprovedInvestigational[L47026] DMD is an X-linked genetic disorder characterized by mutations in the dystrophin gene, leading to a deficiency in functional dystrophin protein. … Microdystrophin is a truncated, functional form of dystrophin.
Oxymorphone
go.drugbank.com/drugs/DB01192ApprovedVet approvedIt may also be used as an adjunct to anesthesia (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092). … An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity.