Search

Displaying results 1671 - 1680 of 3180 in total
  1. Drug

    Binimetinib

    go.drugbank.com/drugs/DB11967
    ApprovedInvestigational

    Binimetinib, also known as Mektovi, is a potent and selective oral mitogen-activated protein kinase 1/2 (MEK 1/2) inhibitor which is combined with Encorafenib. On June 27, 2018, the Food and Drug Administration approved the combination o...

    Categories: Cytochrome P-450 Substrates, P-glycoprotein substrates
  2. Drug

    Ponesimod

    go.drugbank.com/drugs/DB12016
    ApprovedInvestigational

    Ponesimod is a selective sphingosine 1-phosphate receptor 1 modulator indicated in the treatment of relapsing forms of multiple sclerosis in adults. Ponesimod was developed out of a need for a more selective modulator of sphingosine 1-ph...

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  3. Drug

    Lorvotuzumab mertansine

    go.drugbank.com/drugs/DB12089
    Investigational

    Lorvotuzumab mertansine has been used in trials studying the treatment of SCLC, Leukemia, Ovarian Cancer, Multiple Myeloma, and Merkel Cell Carcinoma, among others.

    Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 Inhibitors
  4. Drug

    Secoisolariciresinol

    go.drugbank.com/drugs/DB12179
    Investigational

    Secoisolariciresinol has been used in trials studying the prevention of Breast Cancer.

    Categories: P-glycoprotein inhibitors
  5. Drug

    Estetrol

    go.drugbank.com/drugs/DB12235
    ApprovedInvestigational

    Naturally or synthetically produced steroid estrogens have a wide range of pharmaceutical uses ranging from hormonal contraception to the treatment of menopausal symptoms. Estetrol (E4) is a native estrogen occurring naturally during pre...

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  6. Drug

    Epofolate

    go.drugbank.com/drugs/DB12266
    Investigational

    Epofolate has been used in trials studying the treatment of Advanced Solid Tumors. Epofolate (BMS-753493) is a folate conjugate of the epothilone analog BMS-748285 that was designed to selectively target folate receptor expressing cancer...

    Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 Inhibitors
  7. Drug

    Lynestrenol

    go.drugbank.com/drugs/DB12474
    ApprovedWithdrawn

    Lynestrenol is a progestin and prodrug of norethisterone.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  8. Drug

    Sarcosine

    go.drugbank.com/drugs/DB12519
    Investigational

    Sarcosine has been investigated for the treatment of Schizophrenia.

    Categories: N-substituted Glycines
  9. Drug

    1,2-Benzodiazepine

    go.drugbank.com/drugs/DB12537
    ApprovedInvestigationalWithdrawn

    Benzodiazepine is under investigation for the prevention of Delirium and C.Surgical Procedure; Cardiac. Benzodiazepine has been investigated for the treatment of Obesity, Sleep Apnea, Obstructive, and Disorders of Gallbladder, Biliary Tr...

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  10. Drug

    Piperine

    go.drugbank.com/drugs/DB12582
    Investigational

    Bioperine has been used in trials studying the treatment of Multiple Myeloma and Deglutition Disorders.

    Categories: P-glycoprotein inhibitors, Cytochrome P-450 CYP3A Inhibitors