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Displaying results 1681 - 1690 of 10000 in total
  1. Target

    Protein c-Fos

    go.drugbank.com/bio_entities/BE0001126
    TargetHumans

    In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. … Has a critical function in regulating the development of cells destined to form and maintain the skeleton.

    Polypeptides: Protein c-FosSynonyms: Cellular oncogene fos, Proto-oncogene c-Fos
  2. Drug

    Coagulation factor X human

    go.drugbank.com/drugs/DB13148
    ApprovedInvestigational

    Coagulation Factor X is a vitamin K-dependent, liver-produced serine protease that serves as the first enzyme in the coagulation cascade to form fibrin. … Inherited factor X deficiency is a rare autosomal recessive bleeding disorder that is estimated to occur in 1:1 000 000 individuals up to 1:500 carriers [A31471].

    Synonyms: Factor X, Coagulation factor XMixtures: BERIPLEX P/N 500 POWDER FOR SOLUTION FOR INJECTION, OCTAPLEX POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 500 IU
  3. Indication

    T-Cell/Histiocyte-Rich Large B-Cell Lymphoma

    go.drugbank.com/conditions/DBCOND0082251
    Drugs: Polatuzumab vedotin
    Synonyms: Malignant lymphoma, large B-cell, diffuse, no International Classification of Diseases for Oncology subtype, Malignant lymphoma, large B-cell, diffuse, no ICD-O subtype
  4. Drug

    Cantharidin

    go.drugbank.com/drugs/DB12328
    ApprovedInvestigational

    [A32891, A32892] For its natural purpose, the male blister beetle secretes and presents the cantharidin to a female beetle as a copulatory gift during mating. … [A32892] Nevertheless, it gained its first FDA approval on Jul 21, 2023, under the brand name YCANTH™ by Verrica Pharmaceuticals for the treatment of molluscum contagiosum in adult and pediatric patients

    Categories: Compounds used in a research, industrial, or household setting
  5. Drug

    Fidanacogene elaparvovec

    go.drugbank.com/drugs/DB16783
    ApprovedInvestigational

    [L46691] Hemophilia B is a rare X-linked genetic disorder characterized by abnormal coagulation due to dysfunctional coagulation factor IX with a male incidence estimated to be 1 in 30,000 male births … Factor IX (FIX) deficiency) who are negative for neutralizing antibodies to variant AAV serotype Rh74.

  6. Drug

    Mefenamic acid

    go.drugbank.com/drugs/DB00784
    Approved

    A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.

    Categories: Anti-Inflammatory Agents, Non-Steroidal (Non-Selective), Analgesics, Non-NarcoticSynonyms: N-2,3-xylylanthranilic acid, N-(2,3-xylyl)-2-aminobenzoic acid
  7. Drug

    Olmesartan

    go.drugbank.com/drugs/DB00275
    ApprovedInvestigational

    Olmesartan is commonly used for the management of hypertension and Type 2 Diabetes-associated nephropathy, particularly in patients who are unable to tolerate ACE inhibitors. … ARBs such as olmesartan have been shown in a number of large-scale clinical outcomes trials to improve cardiovascular outcomes including reducing risk of myocardial infarction, stroke, the progression

    Mixtures: OPENVAS CO, ALMETEC-COCategories: Antihypertensive Agents Indicated for Hypertension, Agents Acting on the Renin-Angiotensin System
  8. Drug

    Bulevirtide

    go.drugbank.com/drugs/DB15248
    ApprovedInvestigational

    It was first approved for use in the EU on May 28, 2020; bulevirtide has been granted PRIME scheme eligibility and Orphan Drug Designation by the European Medicines Agency. … [A226305] Bulevirtide, also known as Hepcludex, is a first-in-class entry inhibitor for the treatment of chronic Hepatitis D infection developed by MYR Pharmaceuticals, now part of Gilead.

    Categories: Antivirals for Systemic Use, Antiinfectives for Systemic Use
  9. Drug

    Cyclothiazide

    go.drugbank.com/drugs/DB00606
    Approved

    It is also indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension. … The antihypertensive mechanism of cyclothiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance

  10. Drug

    Clavulanic acid

    go.drugbank.com/drugs/DB00766
    ApprovedInvestigationalVet approved

    [A182228]When it is combined with amoxicillin, clavulanic acid is frequently known as Augmentin, Co-Amoxiclav, or Clavulin.[L7880,L7904,L7910] … Clavulanic acid is a beta-lactamase inhibitor that is frequently combined with [Amoxicillin] or [Ticarcillin] to fight antibiotic resistance by preventing their degradation by beta-lactamase enzymes, broadening

    Mixtures: Co-Amoxiclav for Injection 1.2g, JULMENTIN (2X 457 MG/5ML POWDER FOR SUSPENSION)